剖析RUNX3的功能——硬币的两面
UnPAKing RUNX3 functions-Both sides of the coin.
作者信息
Kumar Arun, Sundaram Sandhya, Rayala Suresh K, Venkatraman Ganesh
机构信息
a Department of Biotechnology , Indian Institute of Technology Madras (IITM) , Chennai , India.
b Departments of Pathology , Sri Ramachandra University , Porur, Chennai , India.
出版信息
Small GTPases. 2019 Jul;10(4):264-270. doi: 10.1080/21541248.2017.1322667. Epub 2017 Jun 23.
Abstract
Post translational modifications of RUNX3 have been shown to play an important role in directing RUNX3 functions. In this review we highlight the phosphorylation dependent functions of RUNX3 as regulated by PAK1 and its implications on tumorigenesis.
摘要
RUNX3的翻译后修饰已被证明在指导RUNX3功能方面发挥重要作用。在本综述中，我们重点介绍了由PAK1调节的RUNX3的磷酸化依赖性功能及其对肿瘤发生的影响。
相似文献
1
UnPAKing RUNX3 functions-Both sides of the coin.剖析RUNX3的功能——硬币的两面
Small GTPases. 2019 Jul;10(4):264-270. doi: 10.1080/21541248.2017.1322667. Epub 2017 Jun 23.
2
Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1-RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function.来自 RUNX3 序列的小肽抑制剂破坏 PAK1-RUNX3 相互作用并消除其磷酸化依赖性致癌功能。
Oncogene. 2021 Aug;40(34):5327-5341. doi: 10.1038/s41388-021-01927-x. Epub 2021 Jul 12.
3
Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions.Pak1对RUNX3上苏氨酸209的磷酸化是其双重功能的分子开关。
Oncogene. 2016 Sep 15;35(37):4857-65. doi: 10.1038/onc.2016.18. Epub 2016 Feb 22.
4
Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells.黄芩素通过AMPKα与MEK/ERK1/2信号通路的相互作用，增加人非小细胞肺癌细胞中RUNX3和FOXO3a的表达及相互作用。
J Exp Clin Cancer Res. 2015 May 7;34(1):41. doi: 10.1186/s13046-015-0160-7.
5
Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction.细胞周期蛋白 D1 通过干扰 RUNX3-p300 相互作用来阻断 RUNX3 的抗增殖功能。
Biochem Biophys Res Commun. 2010 Sep 24;400(3):426-31. doi: 10.1016/j.bbrc.2010.08.094. Epub 2010 Aug 27.
6
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.Src 激酶在酪氨酸残基处磷酸化 RUNX3，并将该蛋白定位于细胞质中。
J Biol Chem. 2010 Mar 26;285(13):10122-10129. doi: 10.1074/jbc.M109.071381. Epub 2010 Jan 25.
7
LncRNA MT1JP Suppresses Gastric Cancer Cell Proliferation and Migration Through MT1JP/MiR-214-3p/RUNX3 Axis.长链非编码RNA MT1JP通过MT1JP/miR-214-3p/RUNX3轴抑制胃癌细胞增殖和迁移。
Cell Physiol Biochem. 2018;46(6):2445-2459. doi: 10.1159/000489651. Epub 2018 May 5.
8
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.Runx3 失活是肺腺癌发生发展的一个关键早期事件。
Cancer Cell. 2013 Nov 11;24(5):603-16. doi: 10.1016/j.ccr.2013.10.003.
9
[Expression of RUNX3 protein in hepatic cell carcinoma and its clinicopathological implications].RUNX3蛋白在肝癌中的表达及其临床病理意义
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Feb;31(2):329-32.
10
RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair.RUNX 多聚（ADP-核糖基）化和 BLM 相互作用促进范可尼贫血途径的 DNA 修复。
Cell Rep. 2018 Aug 14;24(7):1747-1755. doi: 10.1016/j.celrep.2018.07.038.
引用本文的文献
1
Single-Cell RNA Sequencing Reveals Potential Mechanism of RUNX3 Reshaping Tumor Microenvironment in Non-small-cell Lung Cancer.单细胞RNA测序揭示RUNX3重塑非小细胞肺癌肿瘤微环境的潜在机制
Ann Surg Oncol. 2025 Sep 7. doi: 10.1245/s10434-025-18034-w.
2
The Significance of RUNX3 Expression Levels in the Prognosis of Severe Acute Pancreatitis.RUNX3表达水平在重症急性胰腺炎预后中的意义
Int J Gen Med. 2025 Apr 15;18:2133-2139. doi: 10.2147/IJGM.S508172. eCollection 2025.
3
Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications.RUNX 基因家族在肝细胞癌中的多重作用及其潜在的临床意义。
Cells. 2023 Sep 19;12(18):2303. doi: 10.3390/cells12182303.
4
Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1-RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function.来自 RUNX3 序列的小肽抑制剂破坏 PAK1-RUNX3 相互作用并消除其磷酸化依赖性致癌功能。
Oncogene. 2021 Aug;40(34):5327-5341. doi: 10.1038/s41388-021-01927-x. Epub 2021 Jul 12.
本文引用的文献
1
Aurora kinase and RUNX: Reaching beyond transcription.极光激酶与RUNX：超越转录作用
Cell Cycle. 2016 Nov 16;15(22):2999-3000. doi: 10.1080/15384101.2016.1214031. Epub 2016 Aug 5.
2
Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.极光激酶诱导的磷酸化作用将转录因子RUNX排除在染色质之外，以促进有丝分裂的正常进行。
Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6490-5. doi: 10.1073/pnas.1523157113. Epub 2016 May 23.
3
Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions.Pak1对RUNX3上苏氨酸209的磷酸化是其双重功能的分子开关。
Oncogene. 2016 Sep 15;35(37):4857-65. doi: 10.1038/onc.2016.18. Epub 2016 Feb 22.
4
RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma.RUNX3调控胰腺导管腺癌中的转移开关。
Cell. 2015 Jun 4;161(6):1345-60. doi: 10.1016/j.cell.2015.04.048. Epub 2015 May 21.
5
The RUNX family: developmental regulators in cancer.RUNX 家族：癌症中的发育调控因子。
Nat Rev Cancer. 2015 Feb;15(2):81-95. doi: 10.1038/nrc3877. Epub 2015 Jan 16.
6
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.Runx3 失活是肺腺癌发生发展的一个关键早期事件。
Cancer Cell. 2013 Nov 11;24(5):603-16. doi: 10.1016/j.ccr.2013.10.003.
7
Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer.脯氨酰异构酶 Pin1 下调乳腺癌中的抑癌基因 RUNX3。
Oncogene. 2013 Mar 21;32(12):1488-96. doi: 10.1038/onc.2012.178. Epub 2012 May 14.
8
Prognostic significance of RUNX3 expression in human melanoma.RUNX3 表达在人类黑色素瘤中的预后意义。
Cancer. 2011 Jun 15;117(12):2719-27. doi: 10.1002/cncr.25838. Epub 2010 Dec 23.
9
RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.RUNX3 调节肿瘤抑制因子 p53 在丝氨酸 15 位的 DNA 损伤介导的磷酸化，并作为 p53 的共激活因子发挥作用。
J Biol Chem. 2010 May 28;285(22):16693-703. doi: 10.1074/jbc.M109.055525. Epub 2010 Mar 30.
10
RUNX3 is multifunctional in carcinogenesis of multiple solid tumors.RUNX3 在多种实体瘤的致癌作用中具有多功能性。
Oncogene. 2010 May 6;29(18):2605-15. doi: 10.1038/onc.2010.88. Epub 2010 Mar 29.
Zotero 插件