Improvement of avoidance acquisition by the nootropic drug oxiracetam in mice.
作者信息
Sansone M, Castellano C, Ammassari-Teule M
出版信息
Arch Int Pharmacodyn Ther. 1985 May;275(1):86-92.
PMID:2862852
Abstract
The nootropic drug, oxiracetam (25 or 50 mg/kg i.p.), was tested in two inbred strains of mice, subjected to shuttle-box avoidance training. The drug improved avoidance acquisition in good performers BALB/c mice more than in poor performers C57BL/6 mice. In both cases the avoidance facilitating action was evident only if training was preceded by a five-day pretreatment. The nootropic prototype, piracetam (100 mg/kg), facilitated avoidance acquisition in pretreated BALB/c, but not in C57BL/6 mice.
摘要
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