Department of Mental Health and Wellbeing, University of Warwick, Coventry, United Kingdom; Coventry and Warwickshire Partnership NHS Trust, Coventry, United Kingdom.
Warwick Medical School, University of Warwick, United Kingdom.
Psychiatry Res. 2017 Oct;256:102-110. doi: 10.1016/j.psychres.2017.06.027. Epub 2017 Jun 13.
We aimed to elucidate whether schizophrenia and type II diabetes mellitus may present with associated illness severity, in light of accumulating evidence to suggest both conditions have important shared inflammatory components with many shared inflammatory genetic factors.
We conducted a systematic review employing PRISMA criteria, searching EMBASE, Ovid MEDLINE, PsychInfo, Web of Science and Google Scholar to February 1st, 2017, for clinical studies assessing schizophrenia severity alongside dysglycaemia. A narrative synthesis was employed to discuss and compare findings between studies.
Eleven observational studies were included in the analysis. Ten presented evidence in support of an association between schizophrenia severity and dysglycaemia. This association appeared particularly strong regarding negative symptomatology and impaired cognitive function, between which there may be some overlap. Studies examining positive symptomatology returned mixed results.
Whilst study design varied amongst the included studies, the results suggest that further work examining the effect of hyperglycaemia on schizophrenia severity may be relevant, particularly longitudinal studies assessing negative symptomatology and cognitive function. To the authors' knowledge, this is the first systematic review conducted to address this question.
鉴于越来越多的证据表明，精神分裂症和 2 型糖尿病可能具有重要的共同炎症成分和许多共同的炎症遗传因素，我们旨在阐明精神分裂症和 2 型糖尿病是否可能与疾病严重程度相关。
我们按照 PRISMA 标准进行了系统评价，检索了 EMBASE、Ovid MEDLINE、PsychInfo、Web of Science 和 Google Scholar，检索时间截至 2017 年 2 月 1 日，以评估评估精神分裂症严重程度与血糖异常相关的临床研究。采用叙述性综合讨论和比较研究之间的发现。
分析中纳入了 11 项观察性研究。有 10 项研究提供了精神分裂症严重程度与血糖异常之间存在关联的证据。这种关联在阴性症状和认知功能障碍之间似乎特别强烈，两者之间可能存在一些重叠。研究检查阳性症状的结果则不一致。
尽管纳入的研究在研究设计上存在差异，但结果表明，进一步研究高血糖对精神分裂症严重程度的影响可能是相关的，特别是评估阴性症状和认知功能的纵向研究。据作者所知，这是首次针对该问题进行的系统评价。
