Department of Health Sciences, University of Florence, Florence, Italy.
Department of Health Sciences, University of Florence, Florence, Italy.
Psychiatry Res. 2017 Oct;256:111-117. doi: 10.1016/j.psychres.2017.06.042. Epub 2017 Jun 13.
Life events are commonly reported to be related to psychosis. However, less attention has been given to the role that recent events play on psychosis, in relation to exposure to childhood adversity. The current study aimed to evaluate the relationship between recent events and psychosis, taking into account the role of early adversities. 78 psychotic patients and 156 controls were enrolled. Childhood adversity was evaluated using a validated semi-structured interview and the Childhood Experience of Care and Abuse Questionnaire. Recent events were recorded using a semi-structured interview with a normative and contextual approach. The diagnosis of psychosis was made according to Jablenski's criteria. Chi-square, t-test, odds ratio, and binary logistic regression statistical analyses were performed. Psychotic patients reported an excess of recent events. The occurrence of more than one recent event increased the risk of psychosis; there was a cumulative effect between recent and childhood events on psychosis. Recent events were significantly related to psychosis, even in the absence of childhood adversity or when adjusted for it. Our findings suggested that the effect of recent events on psychosis may be amplified by previous exposure to early adversity. Recent events alone, could be also linked to psychosis independently of childhood adversity.
生活事件通常被报道与精神病有关。然而，人们对近期事件在精神病中的作用关注较少，尤其是与儿童期逆境暴露的关系。本研究旨在评估近期事件与精神病之间的关系，同时考虑到早期逆境的作用。共纳入 78 例精神病患者和 156 例对照。采用经过验证的半结构式访谈和儿童期关怀和虐待问卷评估儿童期逆境。采用规范和情境方法的半结构式访谈记录近期事件。根据 Jablenski 标准诊断精神病。进行卡方检验、t 检验、优势比和二元逻辑回归统计分析。精神病患者报告近期事件过多。发生多个近期事件增加了患精神病的风险；近期事件和儿童期事件之间存在累积效应。即使在没有儿童期逆境或在调整了儿童期逆境后，近期事件仍与精神病显著相关。我们的研究结果表明，近期事件对精神病的影响可能因先前暴露于早期逆境而放大。即使没有儿童期逆境，近期事件也可能独立与精神病相关。
