酒精滥用的定量和定性生化参数。

Quantitative and qualitative biochemical parameters for alcohol abuse.

作者信息

Harada S, Agarwal D P, Goedde H W, Miyake K

出版信息

Alcohol. 1985 May-Jun;2(3):411-4. doi: 10.1016/0741-8329(85)90105-3.

Abstract

Blood from alcoholics, non-alcoholic patients and healthy controls were analyzed for various biochemical markers. Follow-up measurements were made during about 3 months of abstention. While a gradual increase in aldehyde dehydrogenase activity (ALDH) in red cell was noted in alcoholic patients serum alpha 1-acid glycoprotein (AAG) values returned to normal range within 8 weeks during abstinence. An additional minor band for alpha 1-antitrypsin (AAT) was observed after isoelectric focusing of sera from alcoholics; this band disappeared after 3 weeks of abstinence. However, no such unusual AAT band was found in non-alcoholic patients with liver disorders.

摘要

对酗酒者、非酗酒患者和健康对照者的血液进行了各种生化标志物分析。在约3个月的戒酒期间进行了随访测量。虽然酗酒患者红细胞中的醛脱氢酶活性（ALDH）逐渐增加，但血清α1-酸性糖蛋白（AAG）值在戒酒8周内恢复到正常范围。对酗酒者的血清进行等电聚焦后，观察到α1-抗胰蛋白酶（AAT）有一条额外的次要条带；这条带在戒酒3周后消失。然而，在患有肝脏疾病的非酗酒患者中未发现这种异常的AAT条带。