Mendonça Carolina R de, Arruda Jalsi T, Noll Matias, Campoli Paulo M de O, Amaral Waldemar N do
Federal University of Goiás, Goiânia, Brazil.
Federal University of Goiás, Goiânia, Brazil.
Eur J Obstet Gynecol Reprod Biol. 2017 Aug;215:153-163. doi: 10.1016/j.ejogrb.2017.06.013. Epub 2017 Jun 7.
This study aimed to assess the prevalence of sexual dysfunction and Female Sexual Function Index (FSFI) score in women with infertility.
A systematic search of the literature was conducted using PubMed, EMBASE, IBECS, and LILACS. The search was limited to articles published from January 2000 to September 2016, without language restriction. Data were analyzed using Stata 12.0. Random effects meta-analyses in weighted mean difference (WMD) were performed for six comparative studies (infertility versus fertility). Heterogeneity was estimated using I. Moreover, to explore the heterogeneity sources among the studies, meta-regression analyses were also performed. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation guidelines, and risk of bias, with a graphic funnel.
Meta-analysis was performed in 11 of 13 comparative studies. The result indicated a significant association between an increase in sexual dysfunction and infertility in women (WMD=-0.16, 95% confidence interval=-0.254 to -0.084, p<0.001), and high heterogeneity between studies was noted (I=98.6%, p<0.000). Meta-regression analysis did not indicate heterogeneity (I=0.00%). We also performed a meta-analysis of individual FSFI domains in 10 studies. Infertile women had problems with lubrication, orgasm, and satisfaction. Meta-regression analysis also showed that heterogeneity had no influence on the final results of all the analyses.
Infertility was associated with an increase in female sexual dysfunction. The most affected areas of sexual function were lubrication, orgasm, and satisfaction.
本研究旨在评估不孕症女性性功能障碍的患病率及女性性功能指数（FSFI）得分。
使用PubMed、EMBASE、IBECS和LILACS对文献进行系统检索。检索限于2000年1月至2016年9月发表的文章，无语言限制。使用Stata 12.0分析数据。对六项比较研究（不孕症与生育能力）进行加权平均差（WMD）的随机效应荟萃分析。使用I统计量估计异质性。此外，为探索研究间异质性来源，还进行了荟萃回归分析。使用推荐评估、制定和评价指南及偏倚风险评估证据质量，并绘制漏斗图。
在13项比较研究中的11项中进行了荟萃分析。结果表明，女性性功能障碍增加与不孕症之间存在显著关联（WMD=-0.16，95%置信区间=-0.254至-0.084，p<0.001），且研究间存在高度异质性（I=98.6%，p<0.000）。荟萃回归分析未显示异质性（I=0.00%）。我们还对10项研究中的FSFI各个领域进行了荟萃分析。不孕女性在润滑、性高潮和满意度方面存在问题。荟萃回归分析还表明，异质性对所有分析的最终结果没有影响。
不孕症与女性性功能障碍增加有关。性功能受影响最严重的方面是润滑、性高潮和满意度。
