State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People's Republic of China.
Research Centre for Analysis and Measurement, Fudan University, Shanghai 200433, People's Republic of China.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:123-129. doi: 10.1016/j.msec.2017.05.010. Epub 2017 May 4.
Photothermal therapy, due to its safety and effectiveness, has attracted tremendous interest in the area of cancer treatment in recent few decades. The emerging of two-dimensional transition metal dichalcogenides has provided this promising therapy with a novel genus of nanomaterials. Herein, we present a facile one-step way to prepare a hybrid of regenerated silk fibroin (RSF) and molybdenum disulfide (MoS) nanosheets simply by directly adding MoS dispersion into RSF aqueous solution to induce the self-assembly of silk protein on the surface of MoS flakes. The produced RSF/MoS hybrids demonstrate better photothermal performance and less cytotoxicity than the pristine MoS. In the meantime, the RSF/MoS hybrids show a good photothermal stability. Finally and importantly, the RSF/MoS hybrids display a satisfying photothermal capability on ablating HeLa cells in vitro, which imply that such a protein/inorganic hybrid material holds a great promise as a photothermal agent in future cancer treatment.
光热疗法由于其安全性和有效性，在近几十年来在癌症治疗领域引起了极大的兴趣。二维过渡金属二硫属化物的出现为这种有前途的治疗方法提供了一种新型的纳米材料。在这里，我们提出了一种简便的一步法，通过直接将 MoS 分散体添加到丝素蛋白（RSF）水溶液中，在 MoS 薄片表面诱导丝蛋白的自组装，从而制备再生丝素蛋白（RSF）和二硫化钼（MoS）纳米片的混合物。与原始 MoS 相比，所制备的 RSF/MoS 杂化物表现出更好的光热性能和更低的细胞毒性。同时，RSF/MoS 杂化物表现出良好的光热稳定性。最后，重要的是，RSF/MoS 杂化物在体外消融 HeLa 细胞方面表现出令人满意的光热性能，这表明这种蛋白质/无机杂化材料有望成为未来癌症治疗中的一种光热剂。
