Lin Jia-Horng, Lee Mong-Chuan, Chen Chih-Kuang, Huang Chien-Lin, Chen Yueh-Sheng, Wen Shih-Peng, Kuo Shu-Ting, Lou Ching-Wen
Innovation Platform of Intelligent and Energy-Saving Textiles, Tianjin Polytechnic University, Tianjin 300387, China; Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan; Department of Chemistry and Chemical Engineering, Minjiang University, Fuzhou 350108, China; School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; Department of Fashion Design, Asia University, Taichung 41354, Taiwan.
Graduate Institute of Biotechnology and Biomedical Engineering, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:481-490. doi: 10.1016/j.msec.2017.04.156. Epub 2017 May 5.
This study prepares biodegradable bone scaffolds helping the recovery of damaged tibias of rats. Polyvinyl alcohol (PVA) plied yarns are fabricated into hollow braids. The braids are combined with hydroxyapatite (HA)/gelatin/PVA mixtures and processed using freeze-thawing and freeze-drying processes in order to form bone scaffolds. These bone scaffolds are observed by scanning electron scope (SEM) and tested for compression strength. Afterwards, recovery of damaged bone, the morphology of the bone, and the histological observation are evaluated. Results indicate a small amount of HA helps in enhancing the compressive strength of bone scaffolds. Results of in vivo assay indicate the damaged tibias of rats recover and function well eight weeks after the implantation, and exhibit a normal morphology. Histological observation confirms the bone scaffolds gradually decompose, allowing tissue infiltration and facilitating ossification. This study successfully produces bone scaffolds with satisfactory mechanical properties helping in the recovery of damaged tibias of rats.
本研究制备了可生物降解的骨支架，以帮助大鼠受损胫骨的恢复。将聚乙烯醇（PVA）复合纱线制成空心编织物。将编织物与羟基磷灰石（HA）/明胶/PVA混合物结合，并通过冻融和冻干工艺进行处理，以形成骨支架。通过扫描电子显微镜（SEM）观察这些骨支架，并测试其抗压强度。之后，评估受损骨的恢复情况、骨的形态以及组织学观察结果。结果表明，少量的HA有助于提高骨支架的抗压强度。体内试验结果表明，大鼠受损胫骨在植入后八周恢复良好且功能正常，并且呈现出正常的形态。组织学观察证实，骨支架逐渐分解，允许组织浸润并促进骨化。本研究成功制备出了具有令人满意力学性能的骨支架，有助于大鼠受损胫骨的恢复。
