Xia Jing, Cheng Xin-Yu, Wang Xiao-Jun, Peng Hong-Juan
1 Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, and Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, School of Public Health, Southern Medical University , Guangzhou, China.
2 Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Medical University , Dongguan, China.
Acta Microbiol Immunol Hung. 2017 Sep 1;64(3):229-244. doi: 10.1556/030.64.2017.016. Epub 2017 Jun 20.
The virulence and pathogenicity of various types of Toxoplasma gondii differ considerably in mice. Recent studies have claimed that similar phenomenon was observed in humans, but no relevant studies have been performed to validate this finding. In addition, reports showing association between a given T. gondii type and outcomes of human infection yielded conflicting results. To provide a more precise estimation of the association and a more reliable conclusion on this subject, we performed this meta-analysis. Relevant literatures were identified in multiple databases and selected based on strict screening. T. gondii-type proportions among different severities of infection were calculated and compared using Fisher's exact test. Pooled odds ratios (OR) were calculated. Our results showed that the difference among T. gondii-type proportions was significant (p < 0.0001). In addition, significant associations were detected between Type I strains infection and congenital toxoplasmosis (OR: 1.91, p = 0.0009), Type III strains infection and pulmonary toxoplasmosis (OR: 5.15, p = 0.04). In our subgroup analysis, Type I strains were significantly associated with cerebral toxoplasmosis in offspring (OR: 1.81, p = 0.02). This result indicated that different types of T. gondii exhibited different virulence and caused different outcomes in humans.
不同类型的弓形虫在小鼠体内的毒力和致病性差异很大。最近的研究称在人类中也观察到了类似现象，但尚未进行相关研究来验证这一发现。此外，关于特定弓形虫类型与人类感染结果之间关联的报告结果相互矛盾。为了更精确地估计这种关联并得出关于该主题更可靠的结论，我们进行了这项荟萃分析。在多个数据库中识别相关文献，并基于严格筛选进行选择。使用Fisher精确检验计算并比较不同感染严重程度中的弓形虫类型比例。计算合并优势比（OR）。我们的结果表明，弓形虫类型比例之间的差异具有显著性（p < 0.0001）。此外，检测到I型菌株感染与先天性弓形虫病之间存在显著关联（OR：1.91，p = 0.0009），III型菌株感染与肺弓形虫病之间存在显著关联（OR：5.15，p = 0.04）。在我们的亚组分析中，I型菌株与后代脑弓形虫病显著相关（OR：1.81，p = 0.02）。这一结果表明，不同类型的弓形虫在人类中表现出不同的毒力并导致不同的结果。
