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新型精神活性物质识别的进展：U.R.I.To.N. 联盟

Advances in new psychoactive substances identification: the U.R.I.To.N. Consortium.

作者信息

Bertol Elisabetta, Vaiano Fabio, Mari Francesco, Di Milia Maria Grazia, Bua Silvia, Supuran Claudiu T, Carta Fabrizio

机构信息

a Forensic Toxicology Division, Department of Health Sciences , University of Florence , Florence , Italy.

b Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Polo Scientifico , Università degli Studi di Firenze , Sesto Fiorentino, Florence , Italy.

出版信息

J Enzyme Inhib Med Chem. 2017 Dec;32(1):841-849. doi: 10.1080/14756366.2017.1333987.

DOI:10.1080/14756366.2017.1333987
PMID:28629236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6445230/
Abstract

Identification of new psychoactive substances (NPS) in biological and non-biological samples represents a hard challenge for forensic toxicologists. Their great chemical variety and the speed with which new NPS are synthesised and spread make stringent the need of advanced tools for their detection based on multidisciplinary approaches. For this reason, in August 2016, the "Unit of Research and Innovation in Forensic Toxicology and Neuroscience of Addiction" (U.R.I.To.N.) was founded by the Forensic Toxicology Division of the University of Florence. In this Research Unit, various professionals (i.e. forensic toxicologists, chemists, physicians) collaborate to study all the aspects of drugs of abuse, especially NPS. Herein, we describe the multidisciplinary approach comprising liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), gas chromatography hyphenated to mass spectrometry (GC-MS) and solution nuclear magnetic resonance analysis that allowed the identification of three NPS such as 1-(benzofuran-5-yl)-N-methylpropan-2-amine, 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethan-1-one (bk-2C-B), and 3-(2-aminopropyl)indole (α-methyltryptamine) in seized materials.

摘要

在生物和非生物样本中鉴定新型精神活性物质（NPS）对法医毒理学家来说是一项艰巨的挑战。它们种类繁多的化学结构以及新型NPS合成和传播的速度，使得基于多学科方法的先进检测工具变得极为必要。因此，2016年8月，佛罗伦萨大学法医毒理学系成立了“法医毒理学与成瘾神经科学研究与创新单元”（U.R.I.To.N.）。在这个研究单元中，各类专业人员（如法医毒理学家、化学家、医生）合作研究滥用药物的各个方面，尤其是新型精神活性物质。在此，我们描述了一种多学科方法，该方法包括液相色谱 - 串联质谱联用（LC-MS/MS）、气相色谱 - 质谱联用（GC-MS）以及溶液核磁共振分析，通过这种方法在查获的物品中鉴定出了三种新型精神活性物质，即1-(苯并呋喃-5-基)-N-甲基丙-2-胺、2-氨基-1-(4-溴-2,5-二甲氧基苯基)乙-1-酮（bk-2C-B）和3-(2-氨基丙基)吲哚（α-甲基色胺）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d14c/6445230/bc6152efff04/IENZ_A_1333987_F0010_B.jpg
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