Criminalistic Institute, Federal District Civil Police , SPO, lote 23, bloco E, 70.610-200, Brasilia, DF, Brazil.
School of Chemistry, University of Lincoln , Brayford Pool, Lincoln LN6 7TS, U.K.
Anal Chem. 2017 Feb 7;89(3):1445-1452. doi: 10.1021/acs.analchem.6b02426. Epub 2017 Jan 6.
The NBOMe derivatives are phenethylamines derived from the 2C class of hallucinogens. Only a few human pharmacologic studies have been conducted on these drugs, and several cases of intoxication and deaths have been reported. Presently, NBOMe are not a part of the routine drugs-of-abuse screening procedure for many police forces, and there are no rapid immunoassay screening tests that can detect the presence of those compounds. In this Article, the voltammetric behavior of 25B NBOMe and 25I NBOMe were investigated and their electroanalytical characteristics determined for the first time. A novel, fast, and sensitive screening method for the identification of the two most common NBOMes (25B-NBOMe and 25I-NBOMe) in real samples is reported. The method uses the electrochemical oxidation of these molecules to produce an analytical signal that can be related to the NBOMe concentration with an average lower limit of quantitation of 0.01 mg/mL for both of them. The method is selective enough to identify the two compounds individually, even given the great similarity in their structure.
NBOMe 衍生物是苯乙胺类物质，源自 2C 类致幻剂。目前仅有少数人体药理学研究涉及这些药物，并且已经报道了几起因中毒和死亡的案例。目前，NBOMe 并未成为许多警察部队常规药物滥用筛查程序的一部分，并且没有能够检测这些化合物存在的快速免疫分析筛选测试。在本文中，首次研究了 25B-NBOMe 和 25I-NBOMe 的伏安行为，并确定了它们的电化学特性。报道了一种新的、快速和灵敏的筛选方法，用于鉴定实际样品中两种最常见的 NBOMe（25B-NBOMe 和 25I-NBOMe）。该方法利用这些分子的电化学氧化产生可与 NBOMe 浓度相关的分析信号，对于两者的平均下限定量均为 0.01mg/mL。该方法具有足够的选择性，可以单独识别这两种化合物，即使它们的结构非常相似。
