白细胞介素-1表达与颞下颌关节紊乱病：文献综述
Expression of Interleukin-1 and temporomandibular disorder: Contemporary review of the literature.
作者信息
Sorenson Adam, Hresko Kyle, Butcher Seth, Pierce Sean, Tramontina Vinicius, Leonardi Rosalia, Loreto Carla, Bosio Jose, Almeida Luis Eduardo
机构信息
a Surgical Sciences Department, Oral Surgery , School of Dentistry, Marquette University , Milwaukee , WI , USA.
b OMFS Department , School of Dentistry, University of California, Los Angeles (UCLA) , Los Angeles , CA , USA.
出版信息
Cranio. 2018 Jul;36(4):268-272. doi: 10.1080/08869634.2017.1342890. Epub 2017 Jun 19.
OBJECTIVE
Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life. A communication network of pro- and anti-inflammatory mediators called cytokines maintains the homeostasis of the TMJ. This review will focus on the Interleukin (IL) family of cytokines, which have been quantified in TMJ synovial fluids in a variety of studies. IL-1α and IL-1β have pro-inflammatory effects, while the endogenous receptor antagonist (IL-1RA) inhibits the pro-inflammatory effects of IL-1.
METHODS
A literature search (2006-2016) to identify eligible studies was completed using the PubMed database. Studies identified used saline irrigation to quantify cytokine profiles in synovial fluid of healthy and/or dysfunctional joints.
RESULTS
The initial search yielded 111 articles, 5 of which met the inclusion criteria after inter-reviewer discussion.
CONCLUSIONS
Articles that compared IL-1 concentrations in TMD vs. control groups found significant differences.
目的
颞下颌关节紊乱病（TMD）是一组影响颞下颌关节（TMJ）的病症，可导致下颌功能障碍、关节和肌肉疼痛以及生活质量下降。一种由促炎和抗炎介质（称为细胞因子）组成的通信网络维持着颞下颌关节的稳态。本综述将聚焦于细胞因子的白细胞介素（IL）家族，在各种研究中已对其在颞下颌关节滑液中的含量进行了量化。IL-1α和IL-1β具有促炎作用，而内源性受体拮抗剂（IL-1RA）可抑制IL-1的促炎作用。
方法
使用PubMed数据库完成了一项文献检索（2006年至2016年），以确定符合条件的研究。所确定的研究使用生理盐水冲洗来量化健康和/或功能失调关节滑液中的细胞因子谱。
结果
初步检索得到111篇文章，经审稿人讨论后，其中5篇符合纳入标准。
结论
比较TMD组与对照组中IL-1浓度的文章发现了显著差异。
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