健康志愿者皮内注射血小板活化因子、组胺和前列腺素E2后的炎症反应：一项双盲研究。
Inflammatory responses to intradermal injection of platelet activating factor, histamine and prostaglandin E2 in healthy volunteers: a double blind investigation.
作者信息
Sciberras D G, Goldenberg M M, Bolognese J A, James I, Baber N S
机构信息
Merck Sharp & Dohme Research Laboratories, Harlow, Essex.
出版信息
Br J Clin Pharmacol. 1987 Dec;24(6):753-61. doi: 10.1111/j.1365-2125.1987.tb03242.x.
Abstract
- The local responses to intradermal injection of PAF, histamine and PGE2 were investigated in eight healthy male volunteers. Acute effects were monitored by weal and flare measurement; delayed effects were investigated by pain threshold testing and skinfold thickness measurements. 2. PAF and PGE2 were found to induce weal and flare responses which were clearly distinguishable from vehicle and dose related. 3. PAF was approximately 50 times as potent as PGE2 at inducing weal on a molar basis. 4. A dose related hyperalgesia was recorded in response to PGE2. No hyperalgesia could be demonstrated following PAF injection compared with vehicle. 5. PAF and histamine elicited an increase in skinfold thickness up to 2 h after injection which was distinguishable from vehicle.
摘要
- 在八名健康男性志愿者中研究了皮内注射血小板活化因子（PAF）、组胺和前列腺素E2（PGE2）后的局部反应。通过风团和红晕测量监测急性效应；通过疼痛阈值测试和皮褶厚度测量研究延迟效应。2. 发现PAF和PGE2可诱导风团和红晕反应，这些反应与赋形剂明显不同且与剂量相关。3. 在摩尔基础上，PAF诱导风团的效力约为PGE2的50倍。4. 记录到对PGE2有剂量相关的痛觉过敏。与赋形剂相比，注射PAF后未显示出痛觉过敏。5. PAF和组胺在注射后长达2小时可引起皮褶厚度增加，这与赋形剂不同。
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