β-肾上腺素受体拮抗剂与非甾体抗炎药联合给药对大鼠结扎诱导心律失常的影响。
The effects of the combined administration of beta-adrenoceptor antagonists and non-steroidal anti-inflammatory drugs on ligation-induced arrhythmias in rats.
作者信息
Fagbemi O
出版信息
Br J Pharmacol. 1985 Jun;85(2):361-5. doi: 10.1111/j.1476-5381.1985.tb08869.x.
Abstract
Pretreatment of anaesthetized rats with intravenously administered beta-adrenoceptor antagonists or non-steroidal anti-inflammatory drugs (NSAIDs) reduced the incidence and severity of ventricular arrhythmia which resulted from acute coronary artery ligation. The beta-adrenoceptor antagonists preferentially suppressed the immediate (Phase 1A) arrhythmia while the NSAIDs suppressed the delayed (Phase 1B) arrhythmias. Combined administration of beta-adrenoceptor antagonists and the NSAIDs produced a more pronounced antiarrhythmic effect than either of the drugs alone.
摘要
给麻醉大鼠静脉注射β-肾上腺素能受体拮抗剂或非甾体抗炎药（NSAIDs）进行预处理，可降低急性冠状动脉结扎所致室性心律失常的发生率和严重程度。β-肾上腺素能受体拮抗剂优先抑制即刻（1A期）心律失常，而非甾体抗炎药抑制延迟（1B期）心律失常。联合使用β-肾上腺素能受体拮抗剂和非甾体抗炎药产生的抗心律失常作用比单独使用任何一种药物都更显著。
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本文引用的文献
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