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β-肾上腺素受体拮抗剂与非甾体抗炎药联合给药对大鼠结扎诱导心律失常的影响。

The effects of the combined administration of beta-adrenoceptor antagonists and non-steroidal anti-inflammatory drugs on ligation-induced arrhythmias in rats.

作者信息

Fagbemi O

出版信息

Br J Pharmacol. 1985 Jun;85(2):361-5. doi: 10.1111/j.1476-5381.1985.tb08869.x.

DOI:10.1111/j.1476-5381.1985.tb08869.x
PMID:2862943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916597/
Abstract

Pretreatment of anaesthetized rats with intravenously administered beta-adrenoceptor antagonists or non-steroidal anti-inflammatory drugs (NSAIDs) reduced the incidence and severity of ventricular arrhythmia which resulted from acute coronary artery ligation. The beta-adrenoceptor antagonists preferentially suppressed the immediate (Phase 1A) arrhythmia while the NSAIDs suppressed the delayed (Phase 1B) arrhythmias. Combined administration of beta-adrenoceptor antagonists and the NSAIDs produced a more pronounced antiarrhythmic effect than either of the drugs alone.

摘要

给麻醉大鼠静脉注射β-肾上腺素能受体拮抗剂或非甾体抗炎药（NSAIDs）进行预处理，可降低急性冠状动脉结扎所致室性心律失常的发生率和严重程度。β-肾上腺素能受体拮抗剂优先抑制即刻（1A期）心律失常，而非甾体抗炎药抑制延迟（1B期）心律失常。联合使用β-肾上腺素能受体拮抗剂和非甾体抗炎药产生的抗心律失常作用比单独使用任何一种药物都更显著。

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本文引用的文献

1
Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size.在麻醉大鼠中进行冠状动脉结扎，作为产生实验性心律失常和测定梗死面积的一种方法。
J Pharmacol Methods. 1980 Jun;3(4):357-68. doi: 10.1016/0160-5402(80)90077-7.
2
Calcium antagonists prevent early post-infarction ventricular fibrillation.钙拮抗剂可预防心肌梗死后早期心室颤动。
Eur J Pharmacol. 1981 Nov 5;75(4):179-85. doi: 10.1016/0014-2999(81)90543-4.
3
Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs.阿司匹林可抑制犬急性冠状动脉闭塞后早期心肌血栓素B2的释放及室性异位活动。
Br J Pharmacol. 1981 Apr;72(4):593-5. doi: 10.1111/j.1476-5381.1981.tb09138.x.
4
The effects of prostaglandins E2, F2 alpha, prostacyclin, flurbiprofen and aspirin on arrhythmias resulting from coronary artery ligation in anaesthetized rats.前列腺素E2、F2α、前列环素、氟比洛芬和阿司匹林对麻醉大鼠冠状动脉结扎所致心律失常的影响。
Br J Pharmacol. 1981 Sep;74(1):155-9. doi: 10.1111/j.1476-5381.1981.tb09968.x.
5
A regimen for low-dose aspirin?低剂量阿司匹林疗法？
Br Med J (Clin Res Ed). 1982 Nov 6;285(6351):1299-302. doi: 10.1136/bmj.285.6351.1299.
6
The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats.阿司匹林、吲哚美辛和甲氯芬那酸钠对麻醉大鼠冠状动脉结扎所致心律失常的影响。
Eur J Pharmacol. 1984 Jan 27;97(3-4):283-7. doi: 10.1016/0014-2999(84)90461-8.
7
The effect of beta-adrenoceptor blocking agents, with differing ancillary properties, on the arrhythmias resulting from acute coronary artery ligation in anaesthetized rats.具有不同辅助特性的β-肾上腺素能受体阻滞剂对麻醉大鼠急性冠状动脉结扎所致心律失常的影响。
Br J Pharmacol. 1983 Aug;79(4):939-46. doi: 10.1111/j.1476-5381.1983.tb10539.x.
8
Anti-platelet activity of beta-adrenergic antagonists: inhibition of thromboxane synthesis and platelet aggregation in patients receiving long-term propranolol treatment.β-肾上腺素能拮抗剂的抗血小板活性：长期接受普萘洛尔治疗患者的血栓素合成抑制及血小板聚集抑制
Lancet. 1981;2(8260-61):1382-4. doi: 10.1016/s0140-6736(81)92800-2.
9
Effect of catecholamines on platelet aggregation caused by thrombin.儿茶酚胺对凝血酶引起的血小板聚集的影响。
Nature. 1967 Jul 15;215(5098):298-9. doi: 10.1038/215298a0.
10
Vasospastic elements in myocardial infarction following coronary occlusion in the dog.
Cardiovasc Res. 1968 Jan;2(1):54-62. doi: 10.1093/cvr/2.1.54.