前列腺素E2、F2α、前列环素、氟比洛芬和阿司匹林对麻醉大鼠冠状动脉结扎所致心律失常的影响。
The effects of prostaglandins E2, F2 alpha, prostacyclin, flurbiprofen and aspirin on arrhythmias resulting from coronary artery ligation in anaesthetized rats.
作者信息
Coker S J, Parratt J R
出版信息
Br J Pharmacol. 1981 Sep;74(1):155-9. doi: 10.1111/j.1476-5381.1981.tb09968.x.
Abstract
1 Various prostaglandins and inhibitors of prostaglandin synthesis were administered prior to acute coronary artery ligation in anaesthetized rats and their effects were assessed on the number and severity of the resulting early arrhythmias (ventricular ectopic activity; incidence and duration of ventricular tachycardia and of ventricular fibrillation). 2 Prostaglandin E2 (PGE2), PGF2 alpha and prostacyclin all showed antiarrhythmic activity; in contrast flurbiprofen increased the incidence of ventricular fibrillation and mortality. 3 Both the number of ventricular ectopic beats and the incidence of ventricular fibrillation were reduced by aspirin. 4 The results suggest that the release of endogenous PGE2, PGF2 alpha and prostacyclin could reduce early post-infarction ventricular arrhythmias whilst the protective effect of aspirin in this model adds further support for the hypothesis that thromboxane release is involved in the genesis of these arrhythmias.
摘要
- 在麻醉大鼠急性冠状动脉结扎前给予各种前列腺素和前列腺素合成抑制剂，并评估它们对由此产生的早期心律失常（室性异位活动；室性心动过速和室颤的发生率及持续时间）的数量和严重程度的影响。2. 前列腺素E2（PGE2）、前列腺素F2α和前列环素均显示出抗心律失常活性；相比之下，氟比洛芬增加了室颤的发生率和死亡率。3. 阿司匹林可减少室性异位搏动的数量和室颤的发生率。4. 结果表明，内源性PGE2、PGF2α和前列环素的释放可减少梗死后早期室性心律失常，而阿司匹林在该模型中的保护作用进一步支持了血栓素释放参与这些心律失常发生的假说。
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