Joly G, Mouillé P, Schmitt H
C R Seances Soc Biol Fil. 1985;179(1):70-3.
In the pithed rat, (imidazolinyl-2)-2 dihydro 2,3 benzofuran or S 9871 and its stereoisomers were found to block alpha-adrenoceptors. In the present investigation the agonistic effect were studied in pithed rats. With (+/-) and (+) S 9871 this effect is compatible with a stimulation of alpha 1-adrenoceptors and the effect of (-) stereoisomer with a stimulation of alpha 1 and alpha 2 adrenoceptors.
在脊髓横断的大鼠中,发现(咪唑啉基-2)-2二氢-2,3-苯并呋喃或S 9871及其立体异构体可阻断α-肾上腺素能受体。在本研究中,对脊髓横断的大鼠的激动作用进行了研究。对于(±)和(+)S 9871,这种作用与α1-肾上腺素能受体的刺激作用相符,而(-)立体异构体的作用则与α1和α2肾上腺素能受体的刺激作用相符。