[二氢苯并呋喃新衍生物S 9871及其立体异构体在脊髓麻醉大鼠中的部分激动剂特性]
[Partial agonist properties of a new derivative of dihydrobenzofuran, S 9871, and its stereoisomers in pithed rats].
作者信息
Joly G, Mouillé P, Schmitt H
出版信息
C R Seances Soc Biol Fil. 1985;179(1):70-3.
PMID:2862976
Abstract
In the pithed rat, (imidazolinyl-2)-2 dihydro 2,3 benzofuran or S 9871 and its stereoisomers were found to block alpha-adrenoceptors. In the present investigation the agonistic effect were studied in pithed rats. With (+/-) and (+) S 9871 this effect is compatible with a stimulation of alpha 1-adrenoceptors and the effect of (-) stereoisomer with a stimulation of alpha 1 and alpha 2 adrenoceptors.
摘要
在脊髓横断的大鼠中，发现（咪唑啉基-2）-2二氢-2,3-苯并呋喃或S 9871及其立体异构体可阻断α-肾上腺素能受体。在本研究中，对脊髓横断的大鼠的激动作用进行了研究。对于（±）和（+）S 9871，这种作用与α1-肾上腺素能受体的刺激作用相符，而（-）立体异构体的作用则与α1和α2肾上腺素能受体的刺激作用相符。
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