[两种新型咪唑啉衍生物及其光学异构体对脊髓麻醉大鼠突触后α肾上腺素能受体的作用]
[Effect of 2 new derivatives of imidazoline and their optical isomers on postsynaptic alpha adrenergic receptors in pithed rats].
作者信息
Joly G, Mouillé P, Dabiré H, Schmitt H
出版信息
C R Acad Sci III. 1984;299(4):73-5.
PMID:6149800
Abstract
The effects of the stereoisomers of two alpha adrenoceptor antagonists [S 10089 (Imidazolinyl-2)-2 benzocyclobutane and S 9871 (Imidazolinyl-2)-2 dihydro 2,3 benzofuran] were studied in pithed Rats. Vasoconstriction elicited via stimulation of alpha 1 adrenoceptors by cirazoline was antagonized, stimulation of alpha 2 adrenoceptors by azepexole was also antagonized by all these derivatives except (-) S 9871 which was ineffective on the pressor response of azepexole.
摘要
在脊髓横断大鼠中研究了两种α肾上腺素能拮抗剂的立体异构体[S 10089（咪唑啉基-2）-2-苯并环丁烷和S 9871（咪唑啉基-2）-2-二氢-2,3-苯并呋喃]的作用。可乐定通过刺激α1肾上腺素能受体引起的血管收缩被拮抗，阿泽哌唑刺激α2肾上腺素能受体引起的反应也被所有这些衍生物拮抗，但（-）S 9871除外，其对阿泽哌唑的升压反应无效。
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