Brondeau P, Martin-Dupont P, Cambar J
C R Seances Soc Biol Fil. 1985;179(1):98-101.
The purpose of the study was to determine a direct vascular effect of beta-blockers on isolated glomeruli of rat kidney. The glomeruli were isolated by sieving and their diameters measured with a micrometer before and after addition of each of three beta-blockers. The diameter of the glomeruli increases (6,7%) with verapamil, a calcium inhibitor, but remains unchanged in the same experimental conditions as well with propranolol, drug which decreases renal plasma flow, than with nadolol and tertatolol, drug increasing renal haemodynamics. The location and the mechanism of the glomerular vasoactivity of these different beta-blockers are discussed.
该研究的目的是确定β受体阻滞剂对大鼠肾脏分离肾小球的直接血管作用。通过筛分分离肾小球，并在添加三种β受体阻滞剂中的每一种之前和之后用千分尺测量其直径。使用钙抑制剂维拉帕米时，肾小球直径增加（6.7%），但在相同实验条件下，降低肾血浆流量的药物普萘洛尔、增加肾血流动力学的药物纳多洛尔和替他洛尔作用下，肾小球直径保持不变。讨论了这些不同β受体阻滞剂肾小球血管活性的位置和机制。
