Martin-Dupont P, Brothier J P, Cambar J
C R Acad Sci III. 1984;299(7):199-204.
The purpose of the present study was to compare the area variations of human cortical and juxtamedullary glomeruli after incubation with verapamil and dopamine. The glomeruli were isolated by sieving; areas were measured by a video analyser. The surface of the cortical glomeruli increases largely with verapamil (+14,3%) and dopamine (+11,5%). But, the area of the juxtamedullary glomeruli remains unchanged in the same experimental conditions. Evidence of such a vasoreactivity difference between cortical and juxtamedullary glomeruli will permit a better understanding in the regulation of renal haemodynamics.
本研究的目的是比较维拉帕米和多巴胺孵育后人皮质肾小球和近髓肾小球的面积变化。通过筛分分离肾小球；用视频分析仪测量面积。皮质肾小球的表面积在维拉帕米（增加14.3%）和多巴胺（增加11.5%）作用下大幅增加。但是，在相同实验条件下近髓肾小球的面积保持不变。皮质肾小球和近髓肾小球之间这种血管反应性差异的证据将有助于更好地理解肾血流动力学的调节。
