Institute of Industrial Ecology and Environment, Zhejiang University, Hangzhou 310028, China.
Institute of Industrial Ecology and Environment, Zhejiang University, Hangzhou 310028, China.
Nitric Oxide. 2018 Feb 28;73:89-95. doi: 10.1016/j.niox.2017.06.006. Epub 2017 Jun 16.
Inhaled nitric monoxide (iNO) is increasingly used as a medical treatment for acute respiratory distress syndrome. A course of the existing nitric monoxide (NO) therapy with gas cylinders could cost up to approximately $15,000 for an average of 30.2 h. Moreover, a gas cylinder containing a mixture of N and NO may potentially leak NO. The objective of this study is to develop an efficient and cost-effective on-site iNO generation system. In the present setup, NO was generated by using dry air or mixed oxygen/nitrogen (O/N) and an AC power source with an output power level of 5-30 W at atmospheric pressure. The simultaneously produced NO was eliminated with an ammonium sulfite ((NH)SO) solution. The effects of the O/N ratio, gas flow rate, discharge gap distance, output energy density and electrode structure on NO concentration and the NO/NO ratio are reported. The concentrations of NO and NO reached 62 ppm and 3 ppm, respectively, after absorption and dilution at a gas flow rate of 6 L/min. With the present setup, the AC arc discharge produced NO at a stable concentration for at least 6 h using dry air.
吸入一氧化氮（iNO）越来越多地被用作急性呼吸窘迫综合征的治疗方法。使用钢瓶的现有一氧化氮（NO）治疗过程可能需要高达约 15000 美元，平均持续 30.2 小时。此外，含有 N 和 NO 的混合气体的钢瓶可能会潜在地泄漏 NO。本研究的目的是开发一种高效且具有成本效益的现场 iNO 生成系统。在当前的设置中，使用干燥空气或混合氧气/氮气（O/N）和输出功率水平为 5-30 W 的交流电源在大气压下产生 NO。同时产生的 NO 用亚硫酸氢铵（(NH)SO）溶液消除。报告了 O/N 比、气体流速、放电间隙距离、输出能量密度和电极结构对 NO 浓度和 NO/NO 比的影响。在气体流速为 6 L/min 的情况下，NO 和 NO 的浓度分别达到 62 ppm 和 3 ppm，经过吸收和稀释后。在当前的设置中，使用干燥空气，交流电弧放电至少以稳定的浓度产生 NO 6 小时。
