Galliera Emanuela, Marazzi Monica Gioia, Gazzaruso Carmine, Gallotti Pietro, Coppola Adriana, Montalcini Tiziana, Pujia Arturo, Corsi Romanelli Massimiliano M
Department of Biomedical, Surgical and Oral Science, Università degli Studi di Milano, Milan, Italy.
IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
Immun Ageing. 2017 Jun 14;14:13. doi: 10.1186/s12979-017-0097-0. eCollection 2017.
Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism.
Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism.
The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis.
骨质疏松症是一种基于骨形成与骨吸收速率随年龄增长失衡的全身性代谢疾病。最近对该疾病发病机制的研究发现，骨质疏松性骨脆性基础上的骨重塑受损可能与蛋白质糖基化以及氧化应激有关。糖基化反应导致糖基化终产物（AGEs）的产生，这些产物进而在骨中积累，并与晚期糖基化终产物受体（RAGE）结合。本研究的目的是探讨循环可溶性RAGE（sRAGE）在骨质疏松症中的潜在作用，特别是评估sRAGE与骨折风险的相关性，以及与骨密度、骨折风险标志物FGF23和脂质代谢的关系。
可溶性RAGE的循环水平与骨质减少和骨质疏松水平相关。血清sRAGE一方面与骨脆性明显相关，另一方面与体重指数（BMI）和瘦素相关。sRAGE特别具有参考价值，因为血清sRAGE作为单一标志物，能够提供有关骨质疏松症两个方面的信息，即骨脆性和脂质代谢。
测定血清sRAGE水平在监测骨质疏松症进展方面可能具有潜在的诊断作用，特别是在从预防和筛查阶段到骨质减少水平再到骨质疏松症的骨折风险评估中。
