Department of Gynecology & Obstetrics, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Road, Xicheng District, Beijing 100050, China.
Biomed Res Int. 2017;2017:8248094. doi: 10.1155/2017/8248094. Epub 2017 May 29.
Abnormal expression of ABCA1 and ABCG1 in the placenta can elicit lipid metabolism disorder and adverse pregnancy outcomes. However, whether it is associated with preterm delivery remains unclear. Our present study aimed to evaluate the relationship between abnormal expression of ABCA1 or ABCG1 and preterm delivery.
Maternal blood and placental tissues from women with spontaneous deliveries (SPD), iatrogenic deliveries (IPD), and term deliveries (TD) were collected. The lipid content and expression of ABCA1 and ABCG1 were subsequently measured.
Compared with IPD and TD groups, the HDL, TD, LDL, and TC levels were lower in the maternal blood but higher (except TC) in the cord blood of the SPD group. The extracellular lipid content in the placentas of the SPD group was also notably lower relative to the IPD and TD groups. Moreover, the protein and mRNA expressions of ABCA1 in the placentas of the SPD group were significantly higher compared with the IPD and TD groups; however, there was no obvious difference among the three groups in the protein and mRNA expressions of ABCG1.
Abnormal expression of ABCA1 may be associated with the dysregulation of placental lipid metabolism and the occurrence or development of SPD.
ABCA1 和 ABCG1 在胎盘的异常表达可引起脂质代谢紊乱和不良妊娠结局。然而，其与早产的关系尚不清楚。本研究旨在评估 ABCA1 或 ABCG1 异常表达与早产的关系。
收集自发性分娩（SPD）、医源性分娩（IPD）和足月分娩（TD）产妇的母血和胎盘组织，检测 ABCA1 和 ABCG1 的脂质含量和表达。
与 IPD 和 TD 组相比，SPD 组母血中 HDL、TD、LDL 和 TC 水平较低，但脐血中 HDL、TD、LDL 和 TC 水平较高（TC 除外）。SPD 组胎盘细胞外脂质含量也明显低于 IPD 和 TD 组。此外，SPD 组胎盘 ABCA1 的蛋白和 mRNA 表达明显高于 IPD 和 TD 组，而三组胎盘 ABCG1 的蛋白和 mRNA 表达无明显差异。
ABCA1 的异常表达可能与胎盘脂质代谢紊乱以及 SPD 的发生或发展有关。
