Oros D, Strunk M, Breton P, Paules C, Benito R, Moreno E, Garcés M, Godino J, Schoorlemmer J
Aragon Institute for Health Research (IIS Aragón), Obstetrics Department, Hospital Clínico Universitario Zaragoza, Spain; Red de Salud Materno Infantil y del Desarrollo (SAMID), RETICS, Instituto de Salud Carlos III (ISCIII), Subdirección General de Evaluación y Fomento de la Investigación, Fondo Europeo de Desarrollo Regional (FEDER), Spain.
Institute for Health Sciences in Aragon (IACS), Sequencing and Functional Genomics, Centro de Investigación Biomédica de Aragón (CIBA), Zaragoza, Spain.
Placenta. 2017 Jul;55:21-28. doi: 10.1016/j.placenta.2017.04.025. Epub 2017 Apr 28.
Suspected preterm labour occurs in around 9% of pregnancies. However, almost two-thirds of women admitted for threatened preterm labour ultimately deliver at term and are considered risk-free for fetal development.
We examined placental and umbilical cord blood samples from preterm or term deliveries after threatened preterm labour as well as term deliveries without threatened preterm labour. We quantitatively analysed the mRNA expression of inflammatory markers (IL6, IFNγ, and TNFα) and modulators of angiogenesis (FGF2, PGF, VEGFA, VEGFB, and VEGFR1).
A total of 132 deliveries were analysed. Preterm delivery and term delivery after suspected preterm labour groups showed similar increases in TNFα expression compared with the term delivery control group in umbilical cord blood samples. Placental samples from preterm and term deliveries after suspected preterm labour exhibited significantly increased expression of TNFα and IL6 and decreased expression of IFNγ. Suspected preterm labour was also associated with altered expression of angiogenic factors, although not all differences reached statistical significance.
We found gene expression patterns indicative of inflammation in human placentas after suspected preterm labour regardless of whether the deliveries occurred preterm or at term. Similarly, a trend towards altered expression of angiogeneic factors was not limited to preterm birth. These findings suggest that the biological mechanisms underlying threatened preterm labour affect pregnancies independently of gestational age at birth.
约9%的妊娠会出现疑似早产情况。然而，因先兆早产入院的女性中，近三分之二最终足月分娩，且被认为胎儿发育无风险。
我们检查了先兆早产之后早产或足月分娩以及无先兆早产的足月分娩的胎盘和脐带血样本。我们定量分析了炎症标志物（IL6、IFNγ和TNFα）和血管生成调节因子（FGF2、PGF、VEGFA、VEGFB和VEGFR1）的mRNA表达。
共分析了132例分娩。与足月分娩对照组相比，疑似早产组之后的早产和足月分娩的脐带血样本中TNFα表达有相似程度的增加。疑似早产之后早产和足月分娩的胎盘样本中TNFα和IL6表达显著增加，IFNγ表达降低。疑似早产还与血管生成因子表达改变有关，尽管并非所有差异都具有统计学意义。
我们发现，无论分娩是早产还是足月，疑似早产后人胎盘均存在指示炎症的基因表达模式。同样，血管生成因子表达改变的趋势并不局限于早产。这些发现表明，先兆早产的生物学机制对妊娠的影响独立于出生时的孕周。
