大疱性类天疱疮患者神经系统疾病的发生率：一项横断面研究。
Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional Study.
作者信息
Khosravani Sheida, Handjani Farhad, Alimohammadi Reyhaneh, Saki Nasrin
机构信息
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Int Sch Res Notices. 2017 May 24;2017:6053267. doi: 10.1155/2017/6053267. eCollection 2017.
BACKGROUND
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND).
OBJECTIVE
The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients.
METHODS
In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19.
RESULTS
Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group ( = 0.022). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group ( = 0.008). In this study, the incidences of Parkinson's disease ( = 0.830), epilepsy ( = 0.067), and multiple sclerosis ( = 0.326) were not statistically significant between the two groups.
CONCLUSION
The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.
背景
大疱性类天疱疮（BP）是一种自身免疫性表皮下大疱性皮肤病，主要发生于老年人。多项研究报告了BP与神经系统疾病（ND）之间的关联。
目的
本研究旨在评估伊朗患者中BP与神经系统疾病之间的关联。
方法
在这项横断面研究中，纳入了87例BP患者。将他们与184例对照进行比较。使用SPSS 19.0统计软件进行统计分析。
结果
在87例BP患者中，17例（19.5%）至少患有一种神经系统疾病。脑血管意外（CVA）是最常见的神经系统疾病，病例组中有7例（8.0%），对照组中有4例（2.1%）。BP患者与对照组之间CVA的发生率有显著差异（P = 0.022）。病例组中有6例患者（16.8%）出现痴呆，对照组中有2例（1.0%）。BP患者与对照组之间痴呆的发生率有显著差异（P = 0.008）。在本研究中，两组之间帕金森病（P = 0.830）、癫痫（P = 0.067）和多发性硬化（P = 0.326）的发生率无统计学意义。
结论
与对照组相比，BP患者中CVA和痴呆的发生率显著更高。
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