Division of Pediatric Nephrology, Hypertension and Pheresis, Washington University in St Louis & St. Louis Children's Hospital, St Louis, MO, USA.
Division of Nephrology, Washington University School of Medicine, St Louis, MO, USA.
Pediatr Nephrol. 2018 Jul;33(7):1113-1122. doi: 10.1007/s00467-017-3712-6. Epub 2017 Jun 19.
Detecting acute rejection in kidney transplantation has been traditionally done using histological analysis of invasive allograft biopsies, but this method carries a risk and is not perfect. Transplant professionals have been working to develop more accurate or less invasive biomarkers that can predict acute rejection or subsequent worse allograft survival. These biomarkers can use tissue, blood or urine as a source. They can comprise individual molecules or panels, singly or in combination, across different components or pathways of the immune system. This review highlights the most recent evidence for biomarker efficacy, especially from multicenter trials.
传统上，通过对有创性同种异体移植活检进行组织学分析来检测肾移植中的急性排斥反应，但这种方法存在风险，并不完美。移植专业人员一直在努力开发更准确或侵入性更小的生物标志物，以预测急性排斥反应或随后的移植物存活率下降。这些生物标志物可以使用组织、血液或尿液作为来源。它们可以由单个分子或多个分子组成的组合，涉及免疫系统的不同组成部分或途径。本综述重点介绍了生物标志物疗效的最新证据，特别是来自多中心试验的证据。
