Zhang Qiuxiang, Zhang Xiaoli, Feng Guijaun, Fu Ting, Yin Rulan, Zhang Lijuan, Feng Xingmei, Li Liren, Gu Zhifeng
School of Nursing, Nantong University, Nantong, China.
Department of Rheumatology, Affiliated Hospital of Nantong University, 20th Xisi Road, 226001, Nantong, People's Republic of China.
Rheumatol Int. 2017 Aug;37(8):1373-1379. doi: 10.1007/s00296-017-3759-5. Epub 2017 Jun 19.
Disease of systemic lupus erythematosus (SLE) and periodontal disease (PD) shares the common multiple characteristics. The aims of the present study were to evaluate the prevalence and severity of periodontal disease in Chinese SLE patients and to determine the association between SLE features and periodontal parameters. A cross-sectional study of 108 SLE patients together with 108 age- and sex-matched healthy controls was made. Periodontal status was conducted by two dentists independently. Sociodemographic characteristics, lifestyle factors, medication use, and clinical parameters were also assessed. The periodontal status was significantly worse in SLE patients compared to controls. In univariate logistic regression, SLE had a significant 2.78-fold [95% confidence interval (CI) 1.60-4.82] increase in odds of periodontitis compared to healthy controls. Adjusted for potential risk factors, patients with SLE had 13.98-fold (95% CI 5.10-38.33) increased odds against controls. In multiple linear regression model, the independent variable negatively and significantly associated with gingival index was education (P = 0.005); conversely, disease activity (P < 0.001) and plaque index (P = 0.002) were positively associated; Age was the only variable independently associated with periodontitis of SLE in multivariate logistic regression (OR 1.348; 95% CI: 1.183-1.536, P < 0.001). Chinese SLE patients were likely to suffer from higher odds of PD. These findings confirmed the importance of early interventions in combination with medical therapy. It is necessary for a close collaboration between dentists and clinicians when treating those patients.
系统性红斑狼疮（SLE）和牙周病（PD）具有共同的多种特征。本研究的目的是评估中国SLE患者牙周病的患病率和严重程度，并确定SLE特征与牙周参数之间的关联。对108例SLE患者和108例年龄及性别匹配的健康对照进行了横断面研究。由两名牙医独立检查牙周状况。还评估了社会人口统计学特征、生活方式因素、药物使用情况和临床参数。与对照组相比，SLE患者的牙周状况明显更差。在单因素逻辑回归中，与健康对照相比，SLE患者患牙周炎的几率显著增加2.78倍[95%置信区间（CI）1.60 - 4.82]。在对潜在风险因素进行调整后，SLE患者与对照组相比患牙周炎的几率增加了13.98倍（95% CI 5.10 - 38.33）。在多元线性回归模型中，与牙龈指数呈负相关且具有显著意义的自变量是受教育程度（P = 0.005）；相反，疾病活动度（P < 0.001）和菌斑指数（P = 0.002）呈正相关；在多因素逻辑回归中，年龄是与SLE患者牙周炎独立相关的唯一变量（OR 1.348；95% CI：1.183 - 1.536，P < 0.001）。中国SLE患者患牙周病的几率可能更高。这些发现证实了早期干预结合药物治疗的重要性。在治疗这些患者时，牙医和临床医生密切合作是必要的。
