性成熟对雌性兔α-肾上腺素能受体的影响。

The effects of sexual maturation on alpha-adrenoceptors in female rabbits.

作者信息

Mishra N, Hamilton C A, Jones C R, Reid J L

出版信息

Eur J Pharmacol. 1985 Jun 7;112(2):243-7. doi: 10.1016/0014-2999(85)90502-3.

Abstract

alpha-Adrenoceptor number and function were examined in brain, platelets, and other peripheral tissues of young (2-3 months) and mature (6-8 months) non pregnant female rabbits. alpha1-Adrenoceptor number was significantly higher in forebrain, hindbrain, spleen and heart of mature rabbits. alpha2-Adrenoceptor number, on the other hand, was found to be significantly lower in platelets, forebrain and spleen but not changed in hindbrain and kidney of mature animals compared to young females. There was a significant reduction in platelet aggregation with maturation. However, no change in in vivo pressor or depressor responses to alpha-adrenoceptor agonists was observed in vivo.

摘要

在年轻（2 - 3个月）和成熟（6 - 8个月）的未孕雌性兔的脑、血小板及其他外周组织中检测了α-肾上腺素能受体的数量和功能。成熟兔前脑、后脑、脾脏和心脏中的α1-肾上腺素能受体数量显著更高。另一方面，与年轻雌性相比，成熟动物的血小板、前脑和脾脏中的α2-肾上腺素能受体数量显著降低，但后脑和肾脏中的α2-肾上腺素能受体数量未发生变化。随着成熟，血小板聚集显著减少。然而，在体内未观察到对α-肾上腺素能受体激动剂的升压或降压反应有变化。