Ardaillou N, Nivez M P, Ardaillou R
FEBS Lett. 1985 Sep 9;189(1):8-12. doi: 10.1016/0014-5793(85)80831-0.
A 23 amino acid synthetic peptide fragment of atrial natriuretic factor (ANF) stimulated guanylate cyclase activity in isolated human glomeruli in a concentration- and time-dependent manner. ANF activated particulate guanylate cyclase whereas it had no effect on soluble guanylate cyclase. These results demonstrate that the glomerulus is a target structure for ANF in humans. They also suggest that ANF-induced increase in glomerular filtration rate is due to a direct effect of this peptide on the glomerular cells mediated by activation of glomerular guanylate cyclase.
心房利钠因子（ANF）的一段由23个氨基酸组成的合成肽片段，以浓度和时间依赖的方式刺激分离的人肾小球中的鸟苷酸环化酶活性。ANF激活颗粒型鸟苷酸环化酶，而对可溶性鸟苷酸环化酶无作用。这些结果表明，肾小球是人体内ANF的靶结构。它们还提示，ANF引起的肾小球滤过率增加是由于该肽通过激活肾小球鸟苷酸环化酶对肾小球细胞产生直接作用所致。
