Kim Young-Min, Kim Jihyun, Lee Ji Young, Kim Minji, Kim Hyunmi, Jung Kwon, Eo Soomi, Ahn Mijin, Ahn Kangmo
The Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
The Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea.
Pediatr Allergy Immunol. 2017 Sep;28(6):551-556. doi: 10.1111/pai.12746.
There are controversial data about the effects of sun exposure on atopic dermatitis (AD). We evaluated the association between solar ultraviolet radiation (UVR) exposure and AD symptoms in children.
Eighty-two children under 6 years (48 boys and 34 girls) with AD living in Seoul, Korea, were enrolled and followed for 12 months between September 2013 and August 2014. Daily symptoms were recorded to describe the degree of itching, sleep disturbance, erythema, dryness, oozing, and edema. We assessed solar UVR by measuring radiation heat flux over the 290-400 nm wavelength range using thermopiles. A generalized linear mixed model and a generalized additive mixed model were used to evaluate the effects of UVR exposure on AD symptoms after adjusting for age, sex, outdoor temperature, outdoor humidity, and ambient air pollution.
Symptom records of 12 915 person-days were analyzed. UVR showed a significantly positive relationship with AD symptoms. Over the study period, an increase in UVR by 10 W/cm was associated with a 1.46% increase in AD symptoms (95% CI: 0.85-2.07) on the exposure day. An increase in the 6-day average level of UVR of the previous 5 days and the current day by 10 W/cm was associated with a 3.58% (95% CI: 2.60-4.56) increase in AD symptoms. UVR exposure significantly increased AD symptoms in autumn, but decreased them in winter.
Atopic dermatitis symptoms in children are likely to be affected by exposure to solar UVR with a cumulative effect, and this effect is different according to season.
关于阳光照射对特应性皮炎（AD）的影响，存在有争议的数据。我们评估了儿童日光紫外线辐射（UVR）暴露与AD症状之间的关联。
招募了82名居住在韩国首尔的6岁以下患有AD的儿童（48名男孩和34名女孩），并在2013年9月至2014年8月期间对他们进行了12个月的随访。记录每日症状以描述瘙痒、睡眠障碍、红斑、干燥、渗出和水肿的程度。我们使用热电堆通过测量290 - 400纳米波长范围内的辐射热通量来评估日光UVR。在调整了年龄、性别、室外温度、室外湿度和环境空气污染后，使用广义线性混合模型和广义相加混合模型来评估UVR暴露对AD症状的影响。
分析了12915人日的症状记录。UVR与AD症状呈显著正相关。在研究期间，暴露日UVR每增加10 W/cm，AD症状增加1.46%（95%CI：0.85 - 2.07）。前5天和当日UVR的6天平均水平每增加10 W/cm，AD症状增加3.58%（95%CI：2.60 - 4.56）。UVR暴露在秋季显著增加AD症状，但在冬季则使其减少。
儿童特应性皮炎症状可能会受到日光UVR暴露的影响，且具有累积效应，并且这种效应因季节而异。
