Singhal Sandeep, Pradeep Avani Raju, Kanoriya Dharmendra, Garg Shruti, Garg Vibhuti
Department of Periodontology, Government Dental College and Research Institute, Bangalore, India.
J Investig Clin Dent. 2018 Feb;9(1). doi: 10.1111/jicd.12279. Epub 2017 Jun 20.
Boric acid (BA) exhibits antibacterial, anti-inflammatory, as well as osteoblastic, activity. The aim of the present study was to explore the efficacy of 0.75% BA gel as a local drug-delivery system in adjunct to scaling and root planing (SRP) for the treatment of class II furcation defects in comparison with placebo gel.
A total of 48 mandibular class II furcation defects were randomized and treated with either 0.75% BA gel or placebo gel. Clinical parameters were recorded at baseline, 3 months, and 6 months, while radiographic parameters were recorded at baseline and 6 months.
Greater mean probing depth reduction and mean relative vertical and horizontal clinical attachment level gain were shown to be greater in group 1 than in group 2 at 3 and 6 months. Furthermore, a significantly greater mean percentage of bone fill was found in group 1 (16.98%±1.03%) than in the placebo (2.86%±0.92%) at 6 months.
The .75% BA group showed significant improvement in clinical parameters compared to placebo gel as an adjunct to SRP. This implies an alternative for treatment of class II furcation.
硼酸（BA）具有抗菌、抗炎以及成骨活性。本研究的目的是探讨0.75% BA凝胶作为局部给药系统辅助龈下刮治和根面平整（SRP）治疗II度根分叉病变的疗效，并与安慰剂凝胶进行比较。
将48例下颌II度根分叉病变随机分组，分别用0.75% BA凝胶或安慰剂凝胶治疗。在基线、3个月和6个月时记录临床参数，在基线和6个月时记录影像学参数。
在3个月和6个月时，第1组的平均探诊深度减少量以及平均相对垂直和水平临床附着水平增加量均大于第2组。此外，在6个月时，第1组的平均骨填充百分比（16.98%±1.03%）显著高于安慰剂组（2.86%±0.92%）。
作为SRP的辅助治疗，0.75% BA组与安慰剂凝胶相比，临床参数有显著改善。这意味着II度根分叉病变的治疗有了一种替代方法。
