Ipshita Sahu, Kurian Ida G, Dileep Pankaj, Kumar Shatrughan, Singh Priyanka, Pradeep Avani R
Department of Periodontology, Government Dental College and Research Institute, Bangalore, Karnataka, India.
Department of Medicine, Employee's State Insurance Postgraduate Institute of Medical Science and Research, Bangalore, Karnataka, India.
J Investig Clin Dent. 2018 Aug;9(3):e12334. doi: 10.1111/jicd.12334. Epub 2018 May 2.
Alendronate (ALN) has antiresorptive and osteostimulative properties. The major component of aloe vera (AV) gel is acemannan, which has been found to have osteogenic properties. The aim of the present study is to explore the effectiveness of 1% ALN and AV gel as an adjunct to scaling and root planing (SRP) in chronic periodontitis patients with class II furcation defects.
Ninety volunteers were randomly assigned to three treatment groups: (a) SRP plus placebo gel; (b) SRP plus 1% ALN gel; and (c) SRP plus AV gel. Clinical and radiographic parameters were recorded at baseline and at 6 and 12 months.
The mean probing depth reduction and relative horizontal clinical attachment level (CAL) and relative vertical CAL gains were greater in the ALN group than in the AV and placebo groups at 6 and 12 months. Furthermore, a significantly greater mean percentage of defect depth reduction (DDR) was found in the ALN group (38.09 ± 9.53, 44.86 ± 6.29) than the AV groups (11.94 ± 15.10, 14.59 ± 25.49) at 6 and 12 months, respectively.
ALN showed significant improvement in all clinical parameters, along with greater DDR, compared to AV in the treatment of class II furcation defects as an adjunct to SRP.
阿仑膦酸盐（ALN）具有抗吸收和骨刺激特性。芦荟（AV）凝胶的主要成分是乙酰化甘露聚糖，已发现其具有成骨特性。本研究的目的是探讨1%ALN和AV凝胶作为慢性牙周炎Ⅱ度根分叉病变患者龈下刮治和根面平整（SRP）辅助治疗手段的有效性。
90名志愿者被随机分为三个治疗组：（a）SRP加安慰剂凝胶；（b）SRP加1%ALN凝胶；（c）SRP加AV凝胶。在基线、6个月和12个月时记录临床和影像学参数。
在6个月和12个月时，ALN组的平均探诊深度减少、相对水平临床附着水平（CAL）和相对垂直CAL增加均大于AV组和安慰剂组。此外，在6个月和12个月时，ALN组的平均缺损深度减少百分比（DDR）（分别为38.09±9.53、44.86±6.29）显著高于AV组（分别为11.94±15.10、14.59±25.49）。
在治疗Ⅱ度根分叉病变作为SRP辅助手段时，与AV相比，ALN在所有临床参数上均显示出显著改善，同时DDR更高。
