廉价膦自由锰前催化剂催化的羰基衍生物转移氢化反应。
Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst.
机构信息
Institut des Sciences Chimiques de Rennes , UMR 6226 CNRS-Université de Rennes 1, Team Organometallics: Materials and Catalysis, 263 avenue du Général Leclerc, Rennes 35042 Cedex, France.
Institut des Sciences Chimiques de Rennes , UMR 6226 CNRS-Université de Rennes 1, Centre de Diffractométrie X, 263 avenue du Général Leclerc, Rennes 35042 Cedex, France.
出版信息
Org Lett. 2017 Jul 7;19(13):3656-3659. doi: 10.1021/acs.orglett.7b01657. Epub 2017 Jun 20.
A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand, 2-(aminomethyl)pyridine, has been developed for the reduction of a large variety of carbonyl derivatives with 2-propanol as hydrogen donor. Remarkably, the reaction proceeds at room temperature with low catalyst loading (down to 0.1 mol %) and exhibits a good tolerance toward functional groups. High TON (2000) and TOF (3600 h) were obtained.
一种非常简单且廉价的催化体系，以丰富的锰作为过渡金属，以廉价的无膦双齿配体 2-（氨甲基）吡啶为配体，已被开发用于用 2-丙醇作为氢供体还原各种羰基衍生物。值得注意的是，该反应在室温下进行，催化剂负载量低（低至 0.1mol%），并且对官能团具有良好的耐受性。TON（2000）和 TOF（3600h）都很高。
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