Ferrero Dennis V, Meyers Holly N, Ferrero Gina M, Schultz Diane E
1 Department of Biological Sciences, University of the Pacific, Lodi, CA, USA.
2 Regional Public Health Laboratory, San Joaquin County Public Health Services, Stockton, CA, USA.
Int J STD AIDS. 2017 Sep;28(10):985-990. doi: 10.1177/0956462416684693. Epub 2016 Dec 20.
Increasing Chlamydia trachomatis (CT) rates and ever-present Neisseria gonorrhoeae (NG) infections in women have given rise in the past to consideration of male screening programs in order to address the silent male reservoir. Non-medical venues (e.g. home collection, restrooms or other private locations) may be viable venues to reach certain populations that in the past have not been accessed. Effortlessly collected, non-invasive, self-collected male specimens that are stable and easy to transport would enhance the success of male screening programs. We designed a head-to-head study to consider the effectiveness of non-invasive self-collected glans/meatal dry swab (SCS) specimens to detect CT and NG nucleic acid when compared to traditional clinician-collected swab (CCS) specimens and first-catch urine (FCU) specimens. A total of 284 male patients were included in the study. Specimens were processed using the Becton Dickinson ProbeTec ET system. The overall sensitivity of SCS was 91.1% with a specificity of 99.2%. There was an overall SCS agreement of 97.7% with CCS specimens and 90.4% with FCU specimens. Dry swab specimens are easy to collect, transport and test. Non-invasive dry self-collected glans/meatal swab specimens are a viable specimen choice.
女性中沙眼衣原体（CT）感染率不断上升以及淋病奈瑟菌（NG）感染一直存在，过去曾促使人们考虑开展男性筛查项目，以解决男性这一隐匿传染源的问题。非医疗场所（如家庭采集、卫生间或其他私密地点）可能是接触某些过去未被触及人群的可行场所。轻松采集、非侵入性、自行采集的男性标本稳定且易于运输，这将提高男性筛查项目的成功率。我们设计了一项对比研究，以探讨与传统的临床医生采集拭子（CCS）标本和首段尿（FCU）标本相比，非侵入性自行采集的龟头/尿道口干拭子（SCS）标本检测CT和NG核酸的有效性。共有284名男性患者纳入该研究。标本采用贝克顿·迪金森公司的ProbeTec ET系统进行处理。SCS的总体灵敏度为91.1%，特异性为99.2%。SCS与CCS标本的总体一致性为97.7%，与FCU标本的总体一致性为90.4%。干拭子标本易于采集、运输和检测。非侵入性自行采集的龟头/尿道口干拭子标本是一种可行的标本选择。
