主要组织相容性单倍型对自身免疫性疾病的影响在不同的近交系鸡家族中有所不同。
Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens.
作者信息
Bacon L D, Rose N R
出版信息
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1435-7. doi: 10.1073/pnas.76.3.1435.
Abstract
Three partially inbred substrains of Obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis. The influence of the major histocompatibility complex (B haplotype) was marked in one, less marked but still significant in a second, and barely detectable and transient in a third substrain. These differences in the effect of B haplotype may be due to the overriding action of genes other than those within the B haplotype.
摘要
对肥胖品系鸡的三个部分近交亚系进行了自身免疫性甲状腺炎自然发病情况的研究。主要组织相容性复合体（B单倍型）的影响在一个亚系中很明显，在第二个亚系中不太明显但仍具有显著性，而在第三个亚系中几乎检测不到且是短暂的。B单倍型效应的这些差异可能是由于B单倍型以外的基因的主导作用。
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