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微创外科手术及其对术后 30 天内并发症、非计划性再入院和死亡率的影响。

Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality.

机构信息

Center for Outcomes Research, Analytics and Evaluation (VCORE), Vattikuti Urology Institute, Henry Ford Hospital, Detroit, Michigan, USA.

Division of Urological Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Br J Surg. 2017 Sep;104(10):1372-1381. doi: 10.1002/bjs.10561. Epub 2017 Jun 20.

Abstract

BACKGROUND

A critical appraisal of the benefits of minimally invasive surgery (MIS) is needed, but is lacking. This study examined the associations between MIS and 30-day postoperative outcomes including complications graded according to the Clavien-Dindo classification, unplanned readmissions, hospital stay and mortality for five common surgical procedures.

METHODS

Patients undergoing appendicectomy, colectomy, inguinal hernia repair, hysterectomy and prostatectomy were identified in the American College of Surgeons National Surgical Quality Improvement Program database. Non-parsimonious propensity score methods were used to construct procedure-specific matched-pair cohorts that reduced baseline differences between patients who underwent MIS and those who did not. Bonferroni correction for multiple comparisons was applied and P < 0·006 was considered significant.

RESULTS

Of the 532 287 patients identified, 53·8 per cent underwent MIS. Propensity score matching yielded an overall sample of 327 736 patients (appendicectomy 46 688, colectomy 152 114, inguinal hernia repair 59 066, hysterectomy 59 066, prostatectomy 10 802). Within the procedure-specific matched pairs, MIS was associated with significantly lower odds of Clavien-Dindo grade I-II, III and IV complications (P ≤ 0·004), unplanned readmissions (P < 0·001) and reduced hospital stay (P < 0·001) in four of the five procedures studied, with the exception of inguinal hernia repair. The odds of death were lower in patients undergoing MIS colectomy (P < 0·001), hysterectomy (P = 0·002) and appendicectomy (P = 0·002).

CONCLUSION

MIS was associated with significantly fewer 30-day postoperative complications, unplanned readmissions and deaths, as well as shorter hospital stay, in patients undergoing colectomy, prostatectomy, hysterectomy or appendicectomy. No benefits were noted for inguinal hernia repair.

摘要

背景

需要对微创外科(MIS)的益处进行严格评估,但目前缺乏相关研究。本研究检查了 MIS 与五种常见手术术后 30 天的结局之间的关联,包括根据 Clavien-Dindo 分级系统评定的并发症、计划外再入院、住院时间和死亡率。

方法

在美国外科医师学院国家外科质量改进计划数据库中,识别出接受阑尾切除术、结肠切除术、腹股沟疝修补术、子宫切除术和前列腺切除术的患者。采用非简约倾向评分方法构建特定手术的配对患者队列,以减少接受 MIS 和未接受 MIS 患者之间的基线差异。对多次比较进行了 Bonferroni 校正,P<0.006 被认为具有统计学意义。

结果

在确定的 532287 例患者中,53.8%接受了 MIS。通过倾向评分匹配得到了一个包含 327736 例患者的总体样本(阑尾切除术 46688 例,结肠切除术 152114 例,腹股沟疝修补术 59066 例,子宫切除术 59066 例,前列腺切除术 10802 例)。在特定手术的配对患者中,MIS 与较低的 Clavien-Dindo 分级 I-II、III 和 IV 级并发症(P≤0.004)、计划外再入院(P<0.001)和缩短住院时间(P<0.001)显著相关,除了腹股沟疝修补术外,在其他四项手术中均如此。MIS 结直肠切除术(P<0.001)、子宫切除术(P=0.002)和阑尾切除术(P=0.002)患者的死亡风险也较低。

结论

MIS 与接受结肠切除术、前列腺切除术、子宫切除术或阑尾切除术患者的术后 30 天并发症、计划外再入院和死亡发生率显著降低,以及住院时间缩短相关,但在腹股沟疝修补术中未观察到益处。

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