单链活化的哈格曼因子的酰胺水解特性。
Amidolytic properties of single-chain activated Hageman factor.
作者信息
Ratnoff O D, Saito H
出版信息
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1461-3. doi: 10.1073/pnas.76.3.1461.
Abstract
Activation of Hageman factor (Factor XII) upon exposure to negatively charged agents has been attributed to proteolytic cleavage of this molecule. To examine this question, purified Hageman factor was exposed to Sephadex gels to which ellagic acid had been adsorbed. Such Hageman factor, separated from the gels and studied in the fluid phase, was amidolytic. Nonetheless, no cleavage of Hageman factor treated in this way could be demonstrated by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Thus, activation of Hageman factor by negatively charged agents was not necessarily accompanied by molecular scission.
摘要
接触带负电荷的物质后，哈格曼因子（因子 XII）的激活被认为是该分子的蛋白水解裂解所致。为了研究这个问题，将纯化的哈格曼因子暴露于吸附了鞣花酸的葡聚糖凝胶。从凝胶中分离出来并在液相中研究的这种哈格曼因子具有酰胺水解活性。然而，通过十二烷基硫酸钠/聚丙烯酰胺凝胶电泳无法证明以这种方式处理的哈格曼因子发生了裂解。因此，带负电荷的物质对哈格曼因子的激活不一定伴随着分子断裂。
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2
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