Department of Analytical Chemistry, School of Sciences, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210046, China.
J Colloid Interface Sci. 2017 Nov 1;505:476-488. doi: 10.1016/j.jcis.2017.04.011. Epub 2017 Apr 6.
In this research, novel polymer grafted-magnetic halloysite nanotubes with norfloxacin loaded (NOR-MHNTs) and controlled-release, was achieved by surface-initiated precipitation polymerization. The magnetic halloysite nanotubes exhibited better adsorption of NOR (72.10mgg) compared with the pristine HNTs (30.80mgg). Various parameters influencing the drug adsorption of the MHNTs for NOR were studied. Polymer grafted NOR-MHNTs has been designed using flexible docking in computer simulation to choose optimal monomers. NOR-MHNTs/poly (methacrylic acid or acrylamide-co-ethylene glycol dimethacrylate) nanocomposite were synthesized using NOR-MHNTs, methacrylic acid (MAA) or acrylamide (AM), ethylene glycol dimethacrylate (EGDMA) and AIBN as nanotemplate, monomers, cross linker and initiator, respectively. The magnetic nanocomposites were characterized by FTIR, TEM, XRD and VSM. The magnetic nanocomposites show superparamagnetic property and fast magnetic response (12.09emug). The copolymerization of monomers and cross linker led to a better sustained release of norfloxacin (>60h) due to the strong interaction formed between monomers and this cationic drug. The cumulative release rate of NOR is closely related to the cross linker amount. In conclusion, combining the advantages of the high adsorption capacity and magnetic proprieties of this biocompatible clay nanotube and the advantages of polymer shell in the enhancement of controlled-sustained release of cationic drug, a novel formulation for the sustained-controlled release of bioactive agents is developed and may have considerable potential application in targeting drug delivery system.
在这项研究中，通过表面引发沉淀聚合，实现了负载诺氟沙星（NOR）的新型聚合物接枝磁性埃洛石纳米管（NOR-MHNTs）及其控制释放。与原始 HNTs（30.80mgg）相比，磁性埃洛石纳米管对 NOR 的吸附性能更好（72.10mgg）。研究了影响 MHNTs 对 NOR 药物吸附的各种参数。通过计算机模拟的柔性对接设计了接枝 NOR 的聚合物，以选择最佳单体。NOR-MHNTs/聚（甲基丙烯酸或丙烯酰胺-co-乙二醇二甲基丙烯酸酯）纳米复合材料是使用 NOR-MHNTs、甲基丙烯酸（MAA）或丙烯酰胺（AM）、乙二醇二甲基丙烯酸酯（EGDMA）和 AIBN 作为纳米模板、单体、交联剂和引发剂分别合成的。通过 FTIR、TEM、XRD 和 VSM 对磁性纳米复合材料进行了表征。磁性纳米复合材料具有超顺磁性和快速磁响应（12.09emug）。单体和交联剂的共聚导致 NOR 的释放更持久（>60h），这是由于单体与这种阳离子药物之间形成的强相互作用。NOR 的累积释放率与交联剂的用量密切相关。总之，结合这种生物相容性粘土纳米管的高吸附能力和磁性特性以及聚合物壳在增强阳离子药物的控制持续释放方面的优势，开发了一种用于生物活性物质持续控制释放的新型制剂，并且可能在靶向药物输送系统中具有相当大的潜在应用。
