Zhao Song, Su Wei, Shah Vishva, Hobson Divia, Yildirimer Lara, Yeung Kelvin W K, Zhao Jinzhong, Cui Wenguo, Zhao Xin
Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
Colloids Surf B Biointerfaces. 2017 Sep 1;157:407-416. doi: 10.1016/j.colsurfb.2017.06.004. Epub 2017 Jun 6.
Tearing of the rotator cuff commonly occurs as among one of the most frequently experienced tendon disorders. While treatment typically involves surgical repair, failure rates to achieve or sustain healing range from 20 to 90%. The insufficient capacity to recover damaged tendon to heal to the bone, especially at the enthesis, is primarily responsible for the failure rates reported. Various types of biomaterials with special structures have been developed to improve tendon-bone healing and tendon regeneration, and have received considerable attention for replacement, reconstruction, or reinforcement of tendon defects. In this review, we first give a brief introduction of the anatomy of the rotator cuff and then discuss various design strategies to augment rotator cuff repair. Furthermore, we highlight current biomaterials used for repair and their clinical applications as well as the limitations in the literature. We conclude this article with challenges and future directions in designing more advanced biomaterials for augmentation of rotator cuff repair.
肩袖撕裂通常是最常见的肌腱疾病之一。虽然治疗通常包括手术修复，但实现或维持愈合的失败率在20%至90%之间。受损肌腱恢复至骨愈合的能力不足，尤其是在肌腱附着点处，是导致所报道失败率的主要原因。已开发出各种具有特殊结构的生物材料来促进肌腱-骨愈合和肌腱再生，并在肌腱缺损的替代、重建或增强方面受到了广泛关注。在本综述中，我们首先简要介绍肩袖的解剖结构，然后讨论增强肩袖修复的各种设计策略。此外，我们重点介绍了目前用于修复的生物材料及其临床应用以及文献中的局限性。我们以设计更先进的生物材料以增强肩袖修复所面临的挑战和未来方向来结束本文。
