Yoon Jong Pil, Kim Hyunjin, Park Sung-Jin, Kim Dong-Hyun, Kim Jun-Young, Kim Du Han, Chung Seok Won
Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Department of Orthopedic Surgery, School of Medicine, Catholic University, Daegu 38430, Republic of Korea.
Biomedicines. 2024 Jul 19;12(7):1613. doi: 10.3390/biomedicines12071613.
Stiffness and adhesions following rotator cuff tears (RCTs) are common complications that negatively affect surgical outcomes and impede healing, thereby increasing the risk of morbidity and failure of surgical interventions. Tissue engineering, particularly through the use of nanofiber scaffolds, has emerged as a promising regenerative medicine strategy to address these complications. This review critically assesses the efficacy and limitations of nanofiber-based methods in promoting rotator cuff (RC) regeneration and managing postrepair stiffness and adhesions. It also discusses the need for a multidisciplinary approach to advance this field and highlights important considerations for future clinical trials.
肩袖撕裂（RCTs）后的僵硬和粘连是常见并发症，会对手术结果产生负面影响并阻碍愈合，从而增加手术干预的发病率和失败风险。组织工程，特别是通过使用纳米纤维支架，已成为一种有前途的再生医学策略来解决这些并发症。本综述批判性地评估了基于纳米纤维的方法在促进肩袖（RC）再生以及处理修复后僵硬和粘连方面的疗效和局限性。它还讨论了采用多学科方法推进该领域的必要性，并强调了未来临床试验的重要注意事项。
