Mehta Prina, Haj-Ahmad Rita, Al-Kinani Ali, Arshad Muhammad Sohail, Chang Ming-Wei, Alany Raid G, Ahmad Zeeshan
Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
School of Pharmacy & Chemistry, Kingston University London, Kingston Upon Thames, KT1 2EE, Surrey, UK.
Ther Deliv. 2017 Jul;8(7):521-541. doi: 10.4155/tde-2017-0018.
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery. A summary table will provide quick reference to note the key findings in this area. In addition, the review also elucidates current theranostic and diagnostic approaches based on ocular lenses.
在过去二十年中，随着纳米技术、智能聚合物系统和多模态功能的出现，药物递送方法已经多样化。针对疾病进行特定治疗的目标是关键的发展参数。一个取得了重大进展的领域是眼部给药。材料的进步、机理概念的发展以及先进工艺技术的应用加速了这一进程。本综述将重点关注基于晶状体的药物递送的发展，同时涉及传统和当前的局部眼部药物递送方法。一个汇总表将提供快速参考，以记录该领域的关键发现。此外，本综述还阐明了基于眼晶状体的当前治疗诊断和诊断方法。
