Departamento de Bioquímica y Biología Molecular, Escuela Universitaria de Óptica, Universidad Complutense de Madrid, Madrid, Spain.
J Ocul Pharmacol Ther. 2013 Mar;29(2):189-99. doi: 10.1089/jop.2012.0212. Epub 2012 Dec 5.
In the ocular pharmacology market, there is a noteworthy unmet demand for more efficacious delivery of ocular therapeutics. Contact lenses are emerging as an alternative ophthalmic drug delivery system to resolve the drawbacks of the conventional topical application methods. Thus, contact lenses drug delivery systems have been developed to provide an increased residence time of the drug at the surface of the eye leading to enhanced bioavailability and more convenient and efficacious therapy. Several research groups have already explored the feasibility and potential of contact lenses loading conventional drugs used to treat anterior eye disorders. Drug incorporation to the lens body is achieved with techniques, like simple soaking, inclusion of drug-loaded colloidal nanoparticles, or molecular imprinting. Regardless of the technique used, key properties of the contact lens, such as transparency and oxygen permeability, should be preserved. In this article, we reviewed the different techniques used for drug delivery through contact lenses, analyzing their advantages and disadvantages, and focused on articles describing contact lens-based ophthalmic drug delivery systems with significant potential to use in ocular therapeutics.
在眼科药理学领域，人们对更有效地输送眼科治疗药物有明显的未满足需求。隐形眼镜作为一种替代眼科药物输送系统，正在被开发出来，以解决传统局部应用方法的缺点。因此，隐形眼镜药物输送系统已经被开发出来，以提供药物在眼睛表面的停留时间增加，从而提高生物利用度和更方便、更有效的治疗效果。已经有几个研究小组探索了将传统药物载入隐形眼镜的可行性和潜力，这些药物用于治疗前眼部疾病。将药物掺入镜片主体是通过简单浸泡、负载药物的胶体纳米粒子的包含或分子印迹等技术来实现的。无论使用哪种技术，隐形眼镜的关键特性，如透明度和氧气透过性，都应得到保留。在本文中，我们综述了通过隐形眼镜进行药物输送的不同技术，分析了它们的优缺点，并重点介绍了描述基于隐形眼镜的眼科药物输送系统的文章，这些系统具有在眼治疗中应用的巨大潜力。
