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伴有中枢神经系统症状的A型急性主动脉夹层的临床特征

Clinical characteristics of type A acute aortic dissection with CNS symptom.

作者信息

Shono Yuji, Akahoshi Tomohiko, Mezuki Satomi, Momii Kenta, Kaku Noriyuki, Maki Jun, Tokuda Kentaro, Ago Tetsuro, Kitazono Takanari, Maehara Yoshihiko

机构信息

Emergency and Critical Care Center, Kyushu University Hospital, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Emergency and Critical Care Center, Kyushu University Hospital, Fukuoka, Japan.

出版信息

Am J Emerg Med. 2017 Dec;35(12):1836-1838. doi: 10.1016/j.ajem.2017.06.011. Epub 2017 Jun 6.

Abstract

BACKGROUND AND PURPOSE

Accurate diagnosis of acute aortic dissection (AAD) is sometimes difficult because of accompanying central nervous system (CNS) symptoms. The purpose of this study was to investigate the clinical characteristics of Type A AAD (TAAAD) with CNS symptoms.

METHODS

We retrospectively reviewed the medical records of 8403 patients ambulanced to our emergency and critical care center between April 2009 and May 2014.

RESULTS

We identified 59 TAAAD patients for the analysis (mean age, 67.3±10.5years; 37 (62.0%) male). Eleven patients (18.6%) presented CNS symptoms at the onset of TAAAD, and these patients complained less frequently of typical chest and back pain than those without CNS symptoms (p<0.0001). Initial systolic and diastolic blood pressure were lower (p=0.003, and p=0.049, respectively) and involvement of the supra-aortic artery was more frequent in patients with CNS symptoms (p<0.0001).

CONCLUSION

Because CNS symptom can mask chest and back pain caused by TAAAD, physicians should always consider the possibility of TAAAD in patients with CNS symptoms in emergency medicine settings.

摘要

背景与目的

由于急性主动脉夹层(AAD)常伴有中枢神经系统(CNS)症状,其准确诊断有时存在困难。本研究旨在探讨伴有CNS症状的A型主动脉夹层(TAAAD)的临床特征。

方法

我们回顾性分析了2009年4月至2014年5月间被救护车送至我院急诊与重症监护中心的8403例患者的病历。

结果

我们确定了59例TAAAD患者进行分析(平均年龄67.3±10.5岁;37例(62.0%)为男性)。11例患者(18.6%)在TAAAD发病时出现CNS症状,与无CNS症状的患者相比,这些患者较少主诉典型的胸痛和背痛(p<0.0001)。有CNS症状的患者初始收缩压和舒张压较低(分别为p=0.003和p=0.049),且主动脉弓上动脉受累更为常见(p<0.0001)。

结论

由于CNS症状可掩盖TAAAD引起的胸痛和背痛,在急诊医学环境中,医生应始终考虑CNS症状患者发生TAAAD的可能性。

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