Blum M D, Bahnson R R, Porter T N, Carter M F
J Urol. 1985 Sep;134(3):479-81. doi: 10.1016/s0022-5347(17)47248-x.
Recent data suggest that selective local blockade of the alpha-adrenergic receptors of the sympathetic innervation within the corpora cavernosa of the penis will result in erection in normal and impotent subjects. To examine this hypothesis we studied in a randomized, double-blinded fashion 8 impotent patients and 2 normal controls. The organic nature of the impotence was documented with nocturnal penile tumescence testing, sacral latency examination, Doppler penile blood flow measurements, hormonal evaluation and psychological testing. The 2 normal controls had full erections for 5 to 7 minutes after the intracorporeal injection of 5 mg. phentolamine. All of the impotent subjects had tumescence without full erection after a similar injection. The tumescence was augmented by standing upright and diminished by assuming a supine posture, and lasted for several hours. Possible mechanisms, and diagnostic and therapeutic implications are discussed.
最近的数据表明，选择性局部阻断阴茎海绵体内交感神经支配的α-肾上腺素能受体会使正常和阳痿患者勃起。为验证这一假设，我们以随机、双盲方式研究了8名阳痿患者和2名正常对照者。通过夜间阴茎肿胀试验、骶髓潜伏期检查、阴茎血流多普勒测量、激素评估和心理测试记录了阳痿的器质性本质。2名正常对照者在海绵体内注射5毫克酚妥拉明后勃起5至7分钟。所有阳痿患者在类似注射后有肿胀但未完全勃起。站立可增强肿胀，仰卧姿势则使其减轻，且持续数小时。文中讨论了可能的机制以及诊断和治疗意义。
