King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Bio-Sciences, Integral University, Lucknow, 226021, India.
Semin Cancer Biol. 2018 Apr;49:56-63. doi: 10.1016/j.semcancer.2017.06.005. Epub 2017 Jun 19.
Hepato-cellular carcinoma (HCC) is one of the frequent cause of cancer-related death worldwide and dominant form of primary liver cancer. However, the reason behind a steady increase in the incidence of this form of cancer remains elusive. Glycation has been reported to play a significant role in the induction of several chronic diseases including cancer. Several risk factors that could induce HCC have been reported in the literature. Deciphering the complex patho-physiology associated with HCC is expected to provide new targets for the early detection, prevention, progression and recurrence. Even-though, some of the causative aspects of HCC is known, the advanced glycation end products (AGEs) related mechanism still needs further research. In the current manuscript, we have tried to uncover the possible role of glycation in the induction of HCC. In the light of the available scientific literature, we advocate in-depth comprehensive studies which will shed light towards mechanistic association of glycation with HCC.
肝细胞癌 (HCC) 是全球癌症相关死亡的常见原因之一，也是原发性肝癌的主要形式。然而，这种癌症发病率稳步上升的原因仍不清楚。糖基化已被报道在诱导包括癌症在内的几种慢性疾病中发挥重要作用。文献中已经报道了几种可能导致 HCC 的危险因素。解析与 HCC 相关的复杂病理生理学有望为早期检测、预防、进展和复发提供新的靶点。即使已经了解了 HCC 的一些病因方面，但与晚期糖基化终产物 (AGEs) 相关的机制仍需要进一步研究。在本手稿中，我们试图揭示糖基化在诱导 HCC 中的可能作用。根据现有科学文献，我们提倡进行深入全面的研究，这将有助于阐明糖基化与 HCC 的机制关联。
