Matheson G K, Eison M S
Methods Find Exp Clin Pharmacol. 1985 May;7(5):231-8.
Buspirone and its analog BMY-13805, clinically effective anxiolytics and their metabolite, 1-PP, were tested on cat spinal reflexes. In the spinal preparation, the monosynaptic reflex and the dorsal root potential were not changed by buspirone, BMY-13805 or 1-PP. Significant changes in the dorsal root potential and monosynaptic reflex were seen after buspirone administration in the intact neuraxis preparation. Generally, these changes had a bimodal pattern, a significant change within 1 hr after buspirone administration, then a period of remittance, followed by a second significant change 3 or more hr later. They included increases in the dorsal root potential and the following changes in the conditioned monosynaptic reflex: an increase in excitatory postsynaptic potential, an increase in postsynaptic inhibition, and decreases in presynaptic inhibition. These data indicate that buspirone does not affect these reflexes directly, but alters supraspinal mechanisms that regulate spinal reflexes.
丁螺环酮及其类似物BMY - 13805是临床上有效的抗焦虑药，对其代谢产物1 - PP进行了猫脊髓反射测试。在脊髓制备中，丁螺环酮、BMY - 13805或1 - PP对单突触反射和背根电位无影响。在完整神经轴制备中给予丁螺环酮后，背根电位和单突触反射出现显著变化。一般来说，这些变化呈双峰模式，给药后1小时内出现显著变化，然后有一段缓解期，随后在3小时或更长时间后出现第二次显著变化。这些变化包括背根电位增加以及条件单突触反射的以下变化：兴奋性突触后电位增加、突触后抑制增加和突触前抑制减少。这些数据表明，丁螺环酮不直接影响这些反射，而是改变调节脊髓反射的脊髓上机制。
