Zachariah Joseph, Rabinstein Alejandro A
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Neurohospitalist. 2017 Jul;7(3):137-140. doi: 10.1177/1941874416684454. Epub 2016 Dec 18.
Electroencephalogram (EEG) reactivity has been increasingly utilized in prognostication after cardiac arrest. Recent studies have demonstrated a false-positive rate of 0% in predicting poor outcome with a nonreactive EEG. The reemergence of reactivity after an initial nonreactive EEG has been noted in cases of drug intoxication, rewarming after hypothermia, and after discontinuing sedation. This is the first case describing the reemergence of EEG reactivity without the confounding factors listed above. We describe a case of resuscitated cardiac arrest with initial EEG demonstrating a lack of reactivity. A repeat EEG completed 3 days later revealed a reemergence of reactivity in the setting of normothermia, a negative drug screen, and the absence of sedation. The delayed recovery of EEG reactivity without previously established confounding factors is novel. Serial EEGs may be beneficial as the available literature on reactivity and prognostication is based on an average of 24 to 48 hours of EEG tracing. Prognostication after cardiac arrest continues to require a multimodal approach.
脑电图(EEG)反应性在心脏骤停后的预后评估中越来越多地被应用。最近的研究表明,在预测脑电图无反应性的不良预后时,假阳性率为0%。在药物中毒、低温后复温以及停用镇静剂的情况下,最初脑电图无反应后反应性会再次出现。这是第一例描述在没有上述混杂因素的情况下脑电图反应性再次出现的病例。我们描述了一例心脏骤停复苏病例,最初的脑电图显示无反应性。3天后完成的重复脑电图显示,在体温正常、药物筛查阴性且无镇静的情况下,反应性再次出现。在没有先前确定的混杂因素的情况下,脑电图反应性延迟恢复是新颖的。由于关于反应性和预后评估的现有文献是基于平均24至48小时的脑电图描记,连续脑电图可能是有益的。心脏骤停后的预后评估仍然需要多模式方法。