Department of Neurology and UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Curr Neurol Neurosci Rep. 2018 Mar 10;18(4):16. doi: 10.1007/s11910-018-0826-6.
This paper aims to review and summarize the key contributions of EEG to prognostication after cardiac arrest (CA).
While there are more EEG patterns predicting poor than good outcome, even EEG patterns previously considered to be "very malignant" may result in survival with a meaningful neurological outcome depending on their underlying etiology as well as the continuity and reactivity of the EEG background. Regardless of the potentially confounding factors, EEG patterns are highly specific with a relatively low false-positive rate. The development of more complex and comprehensive approaches to quantitative EEG analysis could help improve the prognostic value of EEG, but this approach has its own limitations. Seizures and status epilepticus in the setting of CA predict poor outcomes, but it is not clear whether treating them prevents additional brain damage and results in improved outcome. Either continuous EEG or frequent intermittent EEGs should be obtained within the first 12-24 h of return of spontaneous circulation in order to capture highly dynamic and prognostic patterns. Even though EEG has high predictive value for outcomes after cardiac arrest, it should not be the only prognostic tool. Rather, to improve prognostication, EEG should be used in combination with the neurological examination and other ancillary tests.
本文旨在回顾和总结脑电图(EEG)对心脏骤停(CA)后预后的主要贡献。
虽然有更多的 EEG 模式预测不良预后,但即使是以前被认为“非常恶性”的 EEG 模式,也可能由于其潜在病因、EEG 背景的连续性和反应性,导致存活并具有有意义的神经功能预后。无论潜在的混杂因素如何,EEG 模式具有高度特异性,假阳性率相对较低。更复杂和全面的定量 EEG 分析方法的发展可能有助于提高 EEG 的预后价值,但这种方法也有其自身的局限性。CA 情况下的癫痫发作和癫痫持续状态预测不良预后,但尚不清楚治疗这些情况是否可以防止进一步的脑损伤并导致预后改善。为了捕捉高度动态和预后相关的模式,应在自主循环恢复后的最初 12-24 小时内获得连续 EEG 或频繁的间歇性 EEG。尽管 EEG 对心脏骤停后结局具有很高的预测价值,但它不应该是唯一的预后工具。相反,为了改善预后,应将 EEG 与神经系统检查和其他辅助检查结合使用。