Kable Julie A, Coles Claire D
Departments of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park, Atlanta, GA, 30329, USA.
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Child Psychiatry Hum Dev. 2018 Apr;49(2):163-175. doi: 10.1007/s10578-017-0738-8.
The internal validity of the proposed Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE) was evaluated in children diagnosed with either Fetal Alcohol Syndrome (FAS) or partial FAS who were 3-10 years of age and had enrolled in a math intervention study. Symptoms were coded as present or absent using assessments conducted in the study, including standardized measures of neurocognitive and behavioral functioning, parent interview, and direct observations of the child. The number of endorsed ND-PAE symptoms was not related to environmental factors but was moderately related to the child's age. ND-PAE symptoms were highly consistent and this did not vary by age. Evidence suggested the ND-PAE adaptive symptoms may be too restrictive and only one symptom from this domain may be sufficient. Impulsiveness was not related to an endorsement of the ND-PAE disorder but research is needed with other clinical groups to establish the discriminative validity of this symptom.
在一项针对3至10岁、被诊断患有胎儿酒精综合征（FAS）或部分FAS且已参加数学干预研究的儿童中，对拟议的产前酒精暴露相关神经行为障碍（ND-PAE）的内部效度进行了评估。使用该研究中进行的评估（包括神经认知和行为功能的标准化测量、家长访谈以及对儿童的直接观察）将症状编码为存在或不存在。认可的ND-PAE症状数量与环境因素无关，但与儿童年龄呈中度相关。ND-PAE症状高度一致，且不会因年龄而异。有证据表明，ND-PAE适应性症状可能过于严格，该领域仅一个症状可能就足够了。冲动性与对ND-PAE障碍的认可无关，但需要对其他临床群体进行研究，以确定该症状的鉴别效度。
