Chang Zhihui, Zheng Jiahe, Liu Zhaoyu, Guo Qiyong
1 Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Angiology. 2018 Feb;69(2):177-182. doi: 10.1177/0003319717714918. Epub 2017 Jun 21.
We investigated the relationship between the neutrophil-lymphocyte ratio (NLR) and in-stent restenosis (ISR) in patients with femoropopliteal chronic total occlusions (CTOs). The study enrolled 180 patients who had undergone successful stenting treatment for femoropopliteal CTO. Patients with ISR were subsequently classified into 2 groups: early-ISR (within 1 year) and late-ISR (after 1 year). The clinical characteristics, angiographic data, and follow-up data were recorded. The baseline NLR was significantly higher in the early-ISR group than that in the non-ISR group [3.96(2.14) and 3.33(2.73), p = .04]. Receiver operating characteristic curve analysis suggested an optimum early ISR NLR cutoff point of 3.62, which showed a sensitivity and specificity of 73.4% and 80.4%, respectively (area under the curve: 0.707, 95% confidence interval: 0.603-0.792, P < .001). A subgroup analysis was performed based on the NLR value (<3.62 vs ≥3.62). In the NLR ≥3.62 subgroup, the incidence of early ISR was higher than that of late ISR ( P < .01). In the multivariate analysis, NLR ≥3.62 was independently and positively associated with a higher risk of early ISR. In conclusion, NLR is independently associated with early ISR after stent implantation in patients with femoropopliteal CTO.
我们研究了股腘动脉慢性完全闭塞（CTO）患者的中性粒细胞与淋巴细胞比值（NLR）与支架内再狭窄（ISR）之间的关系。该研究纳入了180例接受股腘动脉CTO成功支架治疗的患者。随后，将发生ISR的患者分为2组：早期ISR（1年内）和晚期ISR（1年后）。记录临床特征、血管造影数据和随访数据。早期ISR组的基线NLR显著高于非ISR组[3.96(2.14) 和3.33(2.73)，p = 0.04]。受试者工作特征曲线分析表明，早期ISR的最佳NLR截断点为3.62，其敏感性和特异性分别为73.4%和80.4%（曲线下面积：0.707，95%置信区间：0.603 - 0.792，P < 0.001）。根据NLR值（<3.62 vs ≥3.62）进行亚组分析。在NLR≥3.62亚组中，早期ISR的发生率高于晚期ISR（P < 0.01）。在多变量分析中，NLR≥3.62与早期ISR的较高风险独立且正相关。总之，NLR与股腘动脉CTO患者支架植入后早期ISR独立相关。
