股腘动脉疾病患者中性粒细胞与淋巴细胞比值与药物涂层球囊再狭窄的关系
Relationship Between Neutrophil-Lymphocyte Ratio and Drug-Coated Balloon Restenosis in Patients With Femoropopliteal Arterial Disease.
作者信息
Pan Tao, Tian Shi-Yun, Liu Zhen, Zhang Tao, Li Cheng, Ji Dong-Hua, Wang Feng
机构信息
Department of the Interventional Therapy, 74710First Affiliated Hospital of Dalian Medical University, Dalian, China.
Department of Radiology, 74710First Affiliated Hospital of Dalian Medical University, Dalian, China.
出版信息
Angiology. 2023 Mar;74(3):252-258. doi: 10.1177/00033197221102222. Epub 2022 May 14.
We investigated the relationship between neutrophil-lymphocyte ratio (NLR) and restenosis in patients with femoropopliteal arterial disease following drug-coated balloon (DCB) angioplasty. Patients (n = 120) were divided into 3 groups according to the development of restenosis and the time of restenosis occurrence. The postoperative NLR was higher in the late-restenosis group than that in the no-restenosis group (3.53 vs 2.70; = .011). In multivariate logistic analysis, postoperative NLR was an independent predictor of late restenosis (odds ratio: 1.404, 95% confidence interval: 1.073-1.839; = .014). The postoperative NLR cutoff value for predicting late restenosis was 2.78 with a sensitivity of 80.8% and a specificity of 53.2% (area under the ROC curve was .666 (95% CI: .541-.791, = .010). The incidence of late restenosis in the NLR ≥2.78 group was higher than that in the NLR <2.78 group (32.3 vs 9.1%; = .002). Postoperative NLR is independently associated with late restenosis in patients treated with DCB for femoropopliteal arterial disease.
我们研究了股腘动脉疾病患者在药物涂层球囊（DCB）血管成形术后中性粒细胞与淋巴细胞比值（NLR）与再狭窄之间的关系。根据再狭窄的发生情况和再狭窄出现的时间，将120例患者分为3组。晚期再狭窄组术后NLR高于无再狭窄组（3.53对2.70；P = 0.011）。在多因素逻辑回归分析中，术后NLR是晚期再狭窄的独立预测因素（比值比：1.404，95%置信区间：1.073 - 1.839；P = 0.014）。预测晚期再狭窄的术后NLR临界值为2.78，敏感性为80.8%，特异性为53.2%（ROC曲线下面积为0.666（95%CI：0.541 - 0.791，P = 0.010）。NLR≥2.78组晚期再狭窄的发生率高于NLR<2.78组（32.3%对9.1%；P = 0.002）。对于接受DCB治疗的股腘动脉疾病患者，术后NLR与晚期再狭窄独立相关。
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